Cryptococcosis is an infection caused by the encapsulated yeast, Cryptococcus neoformans, a dimorphic fungus recovered from pigeon excreta, soil, dust and human skin. After a primary infection in the lungs, the
Cryptococcus neoformans is an encapsulated yeastlike fungus. Infection is acquired through direct exposure to bird droppings. The infection is initially characterized by a localized pneumonitis, but when dissemination occurs the CNS is a preferential site for disease, presumably because the CSF is a goo...
Using an established mouse model of cryptococcal meningitis, we found that a majority ofC. neoformanscells in mouse brain tissue exhibited nuclear localization of Mig1 (Fig.2d). Such a high proportion of cells with nucleus-localized Mig1 suggests that brain glucose probably induces Mig1-mediated G...
The disease is caused by pathogenic members of the encapsulated, melanin-forming, basidiomycetous yeast genus Cryptococcus, namely, Cryptococcus neoformans and Cryptococcus gattii species complexes. These two species have different ecological niches across climate zones: C. neoformans has been isolated ...
Cryptococcus is an encapsulated yeast that is found worldwide. Exposure to soil that has been contaminated with bird excrement has been found to be associated with infection. In the pre-AIDS era, symptomatic cryptococcal disease (cryptococcosis) was thought to be an uncommon condition, primarily ...
The animals were injected intratracheally with 250 μg/mL GalXM or PBS. After 24 h, the animals were intratracheally infected with the encapsulated yeast strainC. neoformans(strain B3501 serotype D). Through the hemocytometer count, an inoculum containing 106viable cells (or 5 × 10...
In addition, Cryptococcus can use inositol as a sole carbon source, in which condition, fungal cells remain encapsulated. This phenomenon indicates that inositol may be utilized to regulate capsule production, especially under the condi- tions with abundant inositol, such as inside the brain. To ...
In previous experiments, we tested the effects of chemical inhibitors of Class I and II HDACs (Sodium butyrate and Trichostatin A, respectively) on the expression of virulence-associated phenotypes in the human fungal pathogen C. neoformans. This encapsulated yeast is frequently found in the ...
IMPORTANCE The encapsulated yeast Cryptococcus neoformans and its closely related sister species, Cryptococcus gattii, are ma- jor causes of morbidity and mortality, particularly in immunocompromised persons. This study reports on the preclinical devel- opment of vaccines to protect at-...
Cells grown in minimal medium (MM) had significantly lower density (Fig. 2A to C) than cells grown under nutrient-rich conditions in Sabouraud dextrose broth (Sab) where the capsule was significantly smaller. Cells of the acapsular strain cap59 had significantly higher density than encapsulated ...