This dissemination shows a tropism for the brain and causes a lethal meningoencephalitis that results in 200,000 deaths every year (5). Cryptococcal adaptation to the intracellular and host environment is key to its ability to cause disease. This adaptation begins with transcriptional changes that ...
Cryptococcosis causes disseminated disease in AIDS patients. In contrast to what occurs in laboratory conditions, a large capsule is produced by Cryptococcus neoformans in vivo during infection. The aim of this study was to compare the in vitro activity of different antifungal agents aga...
Recently, we showed that tebuconazole, an environmental triazole, causes Conclusion In conclusion, fungicide PCT exposure selects cells with CR to clinical azole drugs, both in vitro and in vivo. PCT also decreased the virulence of C. gattii R265, after contact with the agrochemical ceased. ...
Background: Cryptococcus neoformans causes serious disease in immunocompromised individuals, leading to over 600,000 deaths per year worldwide. Part of this impact is due to the organism's ability to thwart what should be the mammalian hosts' first line of defense against cryptococcal infection: ...
C. neoformans is a yeast that causes fatal brain infection in close to 200,000 people worldwide every year, mainly afflicting individuals with AIDS or others who are severely immunocompromised. One feature of this microbe that helps it cause disease is that it is able to withstand toxic ...
Additionally, stathmin also causes microtubule-organizing center polarization in activated T cells (40), so there is the possibility that cryptococcal mediated microtubule-organizing center polarization in NK cells is regulated by a Rac → stathmin pathway. In summary, we have demonstrated a novel ...
neoformans causes over 200,000 infections per year with the majority of these occurring in sub-Saharan Africa where HIV rates are high [1–3]. C. neoformans is most commonly known to infect individuals who are immunocompromised, however cases of infections in immunocompetent patients do exist [...
The CSF immune response in HIV-1-associated cryptococcal meningitis: Macrophage activation, correlates of disease severity and effect of antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 2017, 75, 299–307. [CrossRef] [PubMed] 160. Levitz, S.M.; Farrell, T.P. Growth inhibition of ...
Introduction Cryptococcus neoformans is a fungal pathogen that predominantly affects immunocompromised individuals, such as HIV/AIDS patients, in whom it causes chronic meningoencephalitis (CME). Patients with this diagnosis primarily die from CME, with the disease following either an acute infection or ...