(redirected fromCryptochrome) Also found in:Medical,Wikipedia. cryptochromes [′krip·tə‚krōm] (cell and molecular biology) Light-sensitive proteins found in both plants and animals that detect and change conformation in response to blue light; in animals, they play an important role in cir...
R.B. and C.X. provided advice on protein expression. I.A.S. performed molecular dynamics simulations and provided advice on cryptochrome structure and dynamics. L.E.J. had oversight of the organization and administration of the optical spectroscopy measurements. P.J.H., H.M., C.R.T. and...
The structure highlights how the Cry flavin cofactor undergoes conformational changes that couple to large-scale rearrangements at the molecular interface, and how a phosphorylated segment in Tim may impact clock period by regulating the binding of Importin-α and the nuclear import of Tim–Per4,5....
We further developed several monoclonal antibodies to the carboxyl-terminal extension of cCRY4 and localized cCRY4 protein with immunohistochemistry. Consistent with the results of in situ hybridization, cCRY4 immunoreactivity was found in visual pigment cells and cells located at the inner nuclear ...
A multiple alignment of these 54 sequences was constructed with the software package CLUSTAL W 1.74 (Thompson et al., 1994) and modified by visual inspection to move gaps outside the secondary structure elements. We then examined the evolutionary relationships within this protein family with both ...
situ hybridization and found that cCRY4 was likely transcribed in the visual pigment cells, cells in the inner nuclear layer, and retinal ganglion cells.Wefurther developed several monoclonal antibodies to the carboxyl-terminal extension of cCRY4 and localized cCRY4 protein with immunohistochemistry....
Cryptochrome (CRY), a blue light sensor protein, possesses a similar domain structure to photolyase (PHR) that, upon absorption of light, repairs DNA damage. In this review, we compare the reaction dynamics of these systems by monitoring the reaction kinetics of conformational change and ...
Trapping dynamic structural changes of a protein between its active/catalytic and inactive/resting state is a difficult task for scientists looking for structure-function relationships. In the last years, several time-resolved methods have been developed, which provided insight into time-dependent structu...
Cryptochromes (CRY) have been proposed as putative magnetoreceptors in vertebrates. Localisation of CRY1 in the UV cones in the retinas of birds suggested that it could be the candidate magnetoreceptor. However, recent findings argue against this possibi
This review first briefly presents the structure, the photoactivation, and the repair mechanism of CPD and (6-4) photolyase. Next, we review in detail the photoactivation of cryptochromes and CRY-DASH by analyzing the current status of research, as well as the contradictions in the resting ...