Purpose: We previously developed a novel cryo-thermal therapy to treat malignant mammary carcinoma and melanoma in a mouse model; long-term survival and CD4 T cell orchestrating anti-tumor immune memory response were achieved. Moreover, cryo-thermal-induced CD4 T cell differentiation into Th1 and ...
Radiofrequency (RF) ablation of the critical isthmusbetween the tricuspid annulus and the inferior venacava is commonly used to treat typical atrial flutter(AFL).This has become the first line therapy in Europeand in the US due to its high success rate and significantimprovement in quality of ...
Acknowledgements This work is funded in part by a grant from the Center for Innovative Minimally Invasive Therapy (CIMIT) at the Massachusetts General Hospital. The authors are grateful to John Lehmann, MD for his insightful review of this manuscript.References...
An anti-HSP70 antibody was injected intravenously at 6 h after cryo-thermal therapy on days 1 and 2 and mouse survival was monitored. Results Cryo-thermal therapy could trigger the release of DAMPs in situ and in the peripheral circulation, which could downregulate the proportion and suppressive...
Cryo-thermal therapyAdoptive cell therapySolid tumorTumor microenvironmentAdoptive cell therapies (ACT) exhibit excellent efficacy in hematological malignancy. However, its application in solid tumors still has many challenges partly due to the tumor immune microenvironment. Cryo-thermal therapy (CTT) can ...
He, KunLiu, PingXu, Lisa XCell Death & DiseaseHe K, Liu P, Xu LX. The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4þ T-cell-mediated antitumor memory immune response. Cell Death Dis. 2017;8:e2703-e270e.
Therefore, here we combined cryo-thermal therapy with anti-IL-6 treatment to target the MDSC-dominant immunosuppressive environment, thereby optimizing the efficacy of cryo-thermal therapy. We found that combinational treatment significantly increased the long-term survival rate of breast cancer-bearing ...
At a mean of 20 ± 8 month follow-up, there was no significant difference in the chronic clinical efficacy of cryoablation in terms of freedom from AF in the absence of antiarrhythmic drug therapy between using double 5-minute (6/15, 40%) and double 2.5-minute freezes (7/15, 46%, P...
To date injury thresholds for therapy of cardiac and/or PV tissues are largely unreported in the literature. Slices of ventricular myocardium (n=11) and left atrial tissue (n=6) from female Yorkshire Cross swine hearts were dissected including the native endocardial surface. Samples were placed...
Focal therapy is a promising option for localized prostate cancer treatment in low and intermediate risk patients. The combination of minimal invasiveness, disease control and the possibility of re-treatment in case of recurrence have significantly increased interest in focal therapy. However, before ...