RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to developmental disorders. Here we report the cryo-EM structure of elongating human Pol I at 2.7 Å re
(cryo-EM) structures of human B2R-Gqin complex with bradykinin and kallidin at 3.0 Å and 2.9 Å resolution, respectively. The ligand-binding pocket accommodates S-shaped peptides, with aspartic acids and glutamates as an anion trap. The phenylalanines at the tail of the peptides...
Nat. Methods | CryoDRGN: 利用神经网络重建异质cryo-EM结构 今天给大家介绍的是近日发表在Nature Methods上的一篇论文《CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks》。研究人员提出了cryoDRGN,一种使用神经网络从异质单粒子cryo-EM数据集中重建3D密度图的方法。这种方法的强大之...
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[11] Z.Ke et al., Structures and distributionsof SARS-CoV-2 spike proteins on intact virions. Nature 10.1038/s41586-020-2665-2 (2020). [12] B.Turonova et al., In situ structuralanalysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science 10.1126/science.abd5223 ...
Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating 来自 dx.doi.org 喜欢 0 阅读量: 276 作者:L Xu,Q Zheng,R Zhu,Z Yin,N Xia 摘要: Enterovirus uncoating receptors bind at the surface depression ("canyon") that encircles each capsid vertex causing the ...
This progressive spiral assembly might serve, in turn, to organize the icosahedral structures of the underlying membrane and the inner capsid. It is not known, however, which ASFV inner membrane protein(s) may be involved in the interaction with the 5-fold capsid vertex. At present, seven kno...
Structure based rational drug design Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. For Research Use Only. Not for use in diagnostic procedures. ...
Structure based rational drug design Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. For Research Use Only. Not for use in diagnostic procedures. ...
Structure based rational drug design Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. For Research Use Only. Not for use in diagnostic procedures. ...