单颗粒冷冻电镜（SPA cryo-EM）作为现代结构生物学的重要工具，通过独特的三维重建方法实现了对生物大分子的原子级观察。这项技术的核心在于将二维投影图像转化为精确的三维结构模型，其过程融合了物理学与数学的深刻原理。在传统的三维重建方法中，投影匹配技术通过比对未知姿态与参考模型来确定图像方向。然而，由于冷冻电...
SERVICE-Cryo-EMSPA Cryo-EM Services for High Resolution Protein Structure Determination In the past few years, single-particle cryo-EM in particular has triggered a revolution in structural biology and has become a newly dominant discipline.Today,Single Particle Analysis(SPA)is no longer a complement...
Cryo-EM 结构解析技术平台 「青云瑞晶」提供专业的结构解析技术服务,自拥有单晶X射线衍射(XRD)、冷冻电镜单颗粒法(CryoEM-SPA)、MicroED 三种结构解析技术平台,根据蛋白质的不同性质,提供不同的解决方案,结合精良高端的实验设备、经验丰富的高学历科研团队,为您提供从蛋白表达开始的一站式结构解析服务,灵活多样化满足...
Cryo-EM 结构解析技术平台 「青云瑞晶」提供专业的结构解析技术服务,自拥有单晶X射线衍射(XRD)、冷冻电镜单颗粒法(CryoEM-SPA)、MicroED 三种结构解析技术平台,根据蛋白质的不同性质,提供不同的解决方案,结合精良高端的实验设备、经验丰富的高学历科研团队,为您提供从蛋白表达开始的一站式结构解析服务,灵活多样化满足...
The 3D structure of macromolecules provides crucial insights when we explore the unknown world of life sciences. In the wake of technological development, cryo-EM single particle analysis (cryo-EM SPA) technique is widely adopted as the primary method to elucidate many key biological mechanisms at ...
These are: Single Particle Analysis Single particle analysis (SPA) is a well-established cryo-electron microscopy technique, allowing structural biologists to investigate the detailed structures of macromolecules at a near-atomic resolution to uncover rich biological insights. Cryo-Tomography Cryo-electron ...
Using cryo-EM SPA (single particle analysis) technology, Shuimu Biosciences has been able to resolve the three-dimensional conformation of CD73 dimer and full-length antibody complexes, elucidate the non-competitive mechanism of action of antibodies based on spatial e...
Software portfolio for SPA data collection Whether you need end-to-end autonomous screening and real-time quality monitoring or standard automated image acquisition, Thermo Fisher Scientific offers a breadth of solutions to accelerate your single particle analysis data collection. FeatureEPU SoftwareSmart...
Software portfolio for SPA data collection Whether you need end-to-end autonomous screening and real-time quality monitoring or standard automated image acquisition, Thermo Fisher Scientific offers a breadth of solutions to accelerate your single particle analysis data collection. FeatureEPU SoftwareSmart...
SPA EM CharacterizationHot Data CollectionHot Structure DeterminationHot Data Collection 300kV CryoEMHot 120kV CryoEM Protein Production Bacteria Insect Mammalian Cells What cases have we done? Structures Solved by Shuimu Our platform has delivered high-quality cryo-EM and microED structures to over 400...