Despite approval of immunotherapy for wide ranges of cancers, the majority of patients fail to respond to immunotherapy or relapse following initial response which is partially attributed to immunosuppression co-opted by tumor cells. However, it is challenging to utilize conventional methods to ...
Average ages (yrs; ranges) were 63 (48-87) at initial PC diagnosis; 68 (49-89) at first WVU-visit; and 69 (54-89) at first Ra-223 infusion. At diagnosis, 4 men (17%) had prostatectomy; 12 (50%) were M1/stage 4; PSAs ranged from 7-9,600 ng/mL. In 24 men, there were...
Castration-resistant prostate cancer (CRPC) is a highly malignant type of advanced cancer resistant to androgen deprivation therapy. One of the important mechanisms for the development of CRPC is the persistent imbalanced regulation of AR and AR splice v
According to the results from multivariate linear regression, males had higher CRP than females after controlling for the other covariates. However, the Welch Two Samplet-test showed significantly higher CRP in females than males (female: mean = 0.259, male: mean = 0.196;t = 2.866...
Nonnormally distributed variables are presented as medians (interquartile ranges, IQRs), whereas categorical variables are presented as proportions. The Mann–Whitney U test or χ2 test was applied for group comparisons. A two-piecewise linear regression model was applied to determine the inflection...
The tumor microenvironment (TME) concept highlights the participation of immune system cells, extracellular matrix, stromal cells, cancer cells, and signaling molecules in cancer development and response to oncological treatments [7]. Novel approaches for the management of cancer patients should focus on...
CTC medians and ranges are expressed as cells per 7.5 ml of blood. CTC, circulating tumour cell; ECOG, Eastern Collaborative Oncology Group. a P values for nonsignificant associations in the univariate analysis. b P values for multivariate analysis. multivariate analyses indicate that CTC counts at...
(MI) and sudden cardiac death2,3. Diabetes patients are at greater risk for MI morbidity, mortality, and re-infarction compared to non-diabetics4. Chronic hyperglycemia promotes the excessive formation of advanced glycation end products, induces oxidative stress, and causes endothelial dysfunction, ...
It is also well known that CRP is a cardiovascular marker even within ranges considered normal [34–36]. In the present study we found a nearly 4-fold higher concentration of serum hsCRP in non-diabetic patients with IHD together with a strong correlation between serum hsCRP and BMI and ...
On the other hand, it could not be ignored that the coefficients of variation vary in large ranges for both of them50. We review other studies, which also show large variations of serum CRP42,43,44. In our previous work, we also demonstrate the large variations of other proteins in ...