trace elements are essential for the development of the immune system, specifically T-cell proliferation, and differentiation. However, there remain significant gaps in our understanding of the effects of certain trace elements on T-cell
Furthermore, we discuss the current trends of research on the crosstalk mechanisms between trace elements and T-cell immunity. The present review expands our knowledge of the association between trace elements and T-cell immunity and provides an opportunity to utilize the metabolism of trace elements...
www.nature.com/mi REVIEW Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis Dongjia Lin1, Lisa Yang1, Liling Wen1, Huanzi Lu1, Qianming Chen2 and Zhi Wang 1 Oral mucosal disease (OMD), which is also called soft ...
Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising aven
195 Similar studies have found that vitamin C can activate ten-eleven translocation enzymes (TETs), regulating GCB epigenetic modification to promote the differentiation of germinal center B cells into plasma cells, thereby enhancing antibody production.196 Adaptive immunity is achieved through the ...
Adaptive immunity and counterregulatory mechanisms control the intensity and duration of the inflammatory response [16,17]. Cortisol participates in regulating the balance between hyperinflammation and immunosuppression [18], and patients with inadequate cellular corticosteroid activity due to the severity of...
Numerous previous studies have confirmed the critical role of the interaction between CAFs and tumor cells in tumorigenesis and development. However, recently, the mutual effects of CAFs and the tumor immune microenvironment (TIME) have been identified as another key factor in promoting tumor ...
Crosstalk between macrophages and innate lymphoid cells (ILCs) in diseases Author links open overlay panelGuoquan Yin a b 1, Chen Zhao c 1, Weiya Pei a b dShow more Add to Mendeley Share Cite https://doi.org/10.1016/j.intimp.2022.108937Get rights and content...
For instance, in pancreatic ductal adenocarcinoma, using the vitamin D receptor agonist calcipotriol to reprogram stromal cells has shown to curtail tumor growth and improve the efficacy of pancreatic cancer treatments [113]. Such reprogrammed CAFs might release exosomes that possess anti-tumor ...
Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many solid tumours, and this is often accompanied by the contemporary rise of two key iron regulators, HIF2α an