Sex is the prevailing reproductive mode throughout the eukaryotic tree of life [1]. At its core lies a periodic ploidy cycling, accomplished through meiosis, during which haploid gametes are produced, and mating, which ensures the restoration of the original ploidy level. Meiosis, thought to have...
If the mutation of one allele triggers the other then it is a mechanism that occurs relatively frequently, more than would be expected by chance, and the occurrence is more frequent in some lines. In the present context of somatic crossing-over, if one allele mutates to a stable form and...
One possibility is that crossover numbers are limited by interference, and stabilization of Msh4 occurs downstream of the initial crossover patterning process. However, the proteolysis mechanism revealed here for Msh4 could be a more general mechanism, possibly coupled to interference, to regulate ...