Schematic diagram of the cross-talk between cellular senescence and OA. Characteristic manifestations of joint degeneration are as follows: senescent subchondral bone with decreased bone density, reduced bone mass and thinning, senescent infrapatellar fat pad with inflammatory changes, senescent chondrocytes ...
R.Lewis, inEncyclopedia of Genetics, 2001 The First Generation from the Hybrids, and Beyond The fifth section of Mendel's paper shows, repeatedly, that the dominant and recessive forms of each trait appear in a 3:1 ratio in the progeny of hybrids crossed to each other. The numbers speak ...
performed mouse experiments, immunostaining and tissue section analyses. L.G. performed cell-based metabolite screening. P.Y. and C.L. performed in vitro uridine treatment assays and phenotype analysis. S.W. and Y.C. performed single-nucleus isolation of mice muscles. J.L. performed ...
In addition, expression of these isoforms is considered as an important indicator of the presence of stem cells in cultured epithelium grafts for ex vivo regenerative medicine25,28. Moreover, most cultured cells had a normal rat diploid karyotype, even if some aneuploid cells could be observed. ...
an·ti·gen (ăn′tĭ-jən) also an·ti·gene (-jēn′) n. A molecule that is capable of binding to an antibody or to an antigen receptor on a T cell, especially one that induces an immune response. An antigen is usually a foreign substance, such as a toxin or a component ...
The aim of this study was to investigate the cardiovascular mechanisms underlying the acute haemodynamic effects of exogenous lactate infusion in an experimental model of human-sized pigs. Methods In this randomised, blinded crossover study in eight 60-kg-pigs, the pigs received infusions with one...
In the experimental section, after intraperitoneal immunization of the mice with Alum adjuvanted recombinant PspA1-5c+p, we evaluated the immune response, cross-reactivity, and functionality of the Anti-PspA1-5c+p antibody using ELISA, Opsonophagocytic killing activity, and serum bactericidal assay....
To demonstrate the main workflow and primary outputs of the SIAMCAT package (see the “Methods” section and SIAMCAT vignettes), we analyzed a representative dataset [27] consisting of 128 fecal metagenomes from patients with ulcerative colitis (UC) and non-UC controls (Fig.1). UC is a sub...
Human cytomegalovirus (HCMV) has been linked to the triggering of systemic lupus erythematosus (SLE). We proposed that B cell epitope region of HCMV phosphoprotein 65 (HCMVpp65)422–439 mimics an endogenous antigen and initiates lupus-like autoimmunity.
Fig. 1: Capture and characterization of EVs on NPN membranes. aSteps involved in the capture of EVs from the pre-cleared BAL or cell-conditioned media, using SepCon™ centrifuge tubes with a plasma-cleaned NPN chip insert. The insert consists of an ultrathin nanoporous NPN membrane and sil...