讲到这篇论文,上周在南京开会的时候与南大来的前辈王老师聊了会儿,大致总结就是张老师最核心的贡献就是提出了“跨物种调控”(Cross-kingdomregulation)这个理论,然后在这个框架上做了各种各样的发现。这个概念是否正确,以及有多大的意义,要取决于后续的发现,所以这个方面很值得继续探索。 这篇论文不复杂,大致就是金...
It has become clear that flowering plants can respond to bacterial signalling molecules that alter plant growth and development, representing inter-kingdom interaction10,11. The perception of bacteria by plants is of significant importance in terms of monitoring their surroundings and thus being able t...
Finally, we discuss the miRNA-mediated cross-kingdom regulation between diet, host and the gut microbiota. We conclude that, despite many obstacles and challenges, extracellular miRNAs are serious candidates for pharmacological development. 展开
Though more and more exogenous plant miRNAs are experimentally detected in the serum and plasma of human and animals, cross-kingdom regulation of human gene by plant miRNAs is not well understood. It is unclear how exogenous miRNAs evade the RNases and phagocytosis, and maintain stable structures...
Keywords: breast cancer; cross-kingdom regulation; miR159; TCF7 Cell Research (2016) 26:217-228. doi:10.1038/cr.2016.13; published online 22 January 2016 Introduction MicroRNAs (miRNAs), a major family of small RNAs, are ~23 nt-long single strands of RNA that bind to mRNA transcripts to...
Recent studies interestingly suggest a potential cross-kingdom action of plant-derived miRNAs, through dietary intake, in regulating mammalian gene expression. Although the source and scope of plant miRNAs detected in mammalian specimens remain controversial, these initial studies inspired us ...
modulates QS of several Gram-negative bacterial pathogens. Although tryptophol acetate has been previously found in plants and algae [15,16], this is the first report of its production by a yeast and particularly its role as a signaling molecule. The intriguing cross-kingdom communication interfere...
Inter-kingdom cross-talk and its bio-control applications Quorum sensing (QS) molecules are involved in the regulation of complicated processes helping bacterial population benefit from their cell-density. The co-evolution of prokaryotes and eukaryotes raises the prospect of the existence of in... ...
Zhang, L., Hou, D., Chen, X.et al.Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA.Cell Res22, 107–126 (2012). https://doi.org/10.1038/cr.2011.158 Download citation ...
likely expressed during infection. Four of the candidates were produced and confirmed to be P69B inhibitors. This work demonstrates that the use of artificial intelligence to predict cross-kingdom protein complexes can make instrumental contributions to predicting protein functions in host-microbe ...