交叉脱氢偶联反应(Cross Dehydrogenative Coupling (CDC)),由于该反应还在不断发展中,具体的机理研究还没有完全被阐明。
在两个底物的C-H被活化的情况下,利用氢acceptor(氧化剂)的作用,进行的交叉型C-C偶联反应。如果氧化剂是分子状的氧气的话,理论上生成的副产物就是水而已,这样这样的反应就是非常优秀的绿色化学。因此,一旦实现的话这个反应也被认为是终极的,最理想的反应形式。 但是研究现状因为其化学选择性的控制,以及反应性低的...
交叉脱氢偶联反应(Cross Dehydrogenative Coupling (CDC)), 在两个底物的C-H被活化的情况下,利用氢acceptor(氧化剂)的作用,进行的交叉型C-C偶联反应。如果氧化剂是分子状的氧气的话,理论上生成的副产物就是水而已,这样这样的反应就是非常优秀的绿色化学。
Review: 303 refs.doi:10.1002/chin.201522283Krylov Igor B.Vil' Vera A.Terent'ev Alexander O.ChemInformCross-dehydrogenative coupling for the intermolecular C-O bond formation. Krylov I,Terentev O. Beilstein J Org Chem . 2015Igor B K, Vera A V, Alexander O T. Cross-dehydrogenative coupling ...
交叉脱氢偶联反应(Cross Dehydrogenative Coupling (CDC)),在两个底物的C-H被活化的情况下,利用氢acceptor(氧化剂)的作用,进行的交叉型C-C偶联反应。
Review: [116 refs.doi:10.1002/chin.201417278Simon A. GirardThomas KnauberChao‐Jun LiJohn Wiley & Sons, Ltd.CheminformGirard SA, Knauber T, Li CJ (2014) The cross-dehydrogenative coupling of C(sp3)-H bonds: a versatile strategy for C-C bond formations. Angew Chem Int Ed 53:74-100...
In recent years, the cross-dehydrogenative coupling (CDC) has demonstrated to be a powerful synthetic tool to form C–C bonds from two C–H bonds. This high atom-economic transformation is an attractive alternative to the classical substitution and coupling approaches for the benzylation and allyl...
Review: 19 refs.doi:10.1002/chin.201306166ZhuangzhiOrg.-Chem.ShiOrg.-Chem.FrankOrg.-Chem.GloriusOrg.-Chem.ChemInformShi Z, Glorious F. Efficient and versatile synthesis of indoles from enamines and imines by cross-dehydrogenative coupling[J]. Angew Chem Int Ed, 2012, 51(37): 9220–9222. ...
Here we have developed an effective metal-free dehydrogenative coupling method wherein α-oxyalkyl and alkyl radicals were generated from various ethers and alkanes to undergo coupling with a variety of electron-deficient heteroarenes such as un/substituted iso-quinolones, quinolines, pyridines, pyrazine...
A range of heterocyclic compounds were synthesized by a novel, metal-free cross-dehydrogenative coupling between heterocycles and aldehydes under mild reaction conditions that are not sensitive to moisture. The products are formed smoothly and regioselectively at room temperature by a hypervalent iodine ...