黏附性大肠杆菌(AIEC)在患有CD的人中更为常见, 与非AIEC菌株相比,具有与高粘附力和侵袭指数相关的坚固的生物膜的能力[ 94] 的嗜中性粒细胞,并在自体溶酶体步骤的能力块自噬,这允许细菌细胞内生存和炎症的诱导。不论基因型如何,炎症都会导致回肠的AIEC增殖和营养不良。 AIEC菌株在巨噬细胞内大量复制,从而诱导大...
附着性侵袭性大肠杆菌(AIEC)更常见于患有CD的人,它们具有与非AIEC菌株相比更强的生物膜形成能力,与高粘附和侵袭指数相关联对中性粒细胞和自噬过程的阻断能力,这使细菌能够在细胞内存活并诱导炎症。炎症促进AIEC的增殖和回肠中的菌群失调,与基因型无关。 AIEC菌株在巨噬细胞内大量复制,诱导分泌大量TNF-α。 Mouse ...
The AIEC strains were phylogenetically heterogeneous. We did not identify a gene (or nucleic acid base composition differences) common to all, or the majority of, AIEC. Cytokine secretion and CRISPRs were not associated with the AIEC phenotype.Conclusions: Comparative genomic analysis of AIEC and ...
The increased adherence and invasion capabilities of AIEC enable these bacteria to penetrate the mucus layer more easily [122]. Another study conducted highlighted that compared to healthy individuals, patients with CD and their relatives exhibit enhanced mucin degradation capacity in their gut bacteria,...
Adherent-invasive Escherichia coli (AIEC), associated with Crohn’s disease, are likely candidate contributory factors in the disease. However, signaling pathways involved in human intestinal mucosa innate host response to AIEC remain unknown. Here we us
coli, increased in Crohn's disease, replicate within macrophages and may have a primary pathogenic role. Crohn's disease patients' macrophages may have a primary defect in bacterial killing, allowing survival of AIEC. Methods We aimed to assess the relative ability of monocyte-derived macrophages ...
Here, we show that macrophages are abundant in human IBD-fibrosis tissue and mouse fibrotic lesions, where they co-localize with AIEC. Ybt induces profibrotic gene expression in macrophages via stabilization and nuclear translocation of hypoxia-inducible factor 1-alpha (HIF-1α), a metal-dependent...
(AIEC), originally isolated from patients with CD, has the ability to penetrate the mucus layer and attach to intestinal epithelial cell lines via type 1 fimbrial adhesion8, suggesting a crucial role of this bacterial function in inducing intestinal inflammation. Additionally, theEscherichia coli...
AIEC adherent-invasiveEscherichia coli; AKT protein kinase B; CD Crohn’s disease; COX2 cyclooxygenase 2; DSS dextran sulfate sodium; EHEC enterohemorrhagicEscherichia coli; ER endoplasmic reticulum; ERK extracellular signal-regulated kinase; Fxr farnesoid X receptor; ...
genes in a genome is unreasonable. However, the genes identified can be considered genetic determinants conferring a high level of fitness to CD-associated strains in the human gut (based on their high abundance). This hypothesis is supported by the fact that in addition to AIEC and several ...