[5]Overexpression and purification of the recombinant diphtheria toxin variant CRM197 in Escherichia coli. Protein Expression and Purification. PMID: 21889551. [6]Malito, Enrico et al. “Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.” Proceedings of the National Acad...
产品分子量：58.4 kDa 纯度：>95% CRM197 by SE-HPLC or RP-HPLC or SDS-PAGE 内毒素：<100 EU/mg of protein by LAL method 二聚物：<5% 特点 （1）避免了在病原微生物中缓慢，复杂和昂贵的生产 （2）与其他的表达系统获得的CRM197相比，Pfenex的纯度更高 （3）提供研究用和cGMP等级的重组CRM197...
参考文献: [1]Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity. Journal of Biological Chemistry. PMID: 17988701. [2]Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. Journal of Neurochemistry. PMID: 20082134. [3...
At Primrose Bio, we leverage CRM197 carrier protein to enhance conjugate vaccines, improving immune responses and contributing to innovative, effective solutions for global health.
[1]Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity. Journal of Biological Chemistry. PMID: 17988701. [2]Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. Journal of Neurochemistry. PMID: 20082134. ...
[1]Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity. Journal of Biological Chemistry. PMID: 17988701. [2]Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. Journal of Neurochemistry. PMID: 20082134. ...
Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity. PMID: 17988701 Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. PMID: 20082134 Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the...
CRM197 is a non-toxic mutant of diphtheria toxin having a single amino acid substitution of glycine with glutamic acid. CRM197 is a well-defined protein and functions as a carrier for polysaccharides and haptens making them more immunogenic. CRM197 is utilized as a carrier protein in a number...
Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity. PMID: 17988701 Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. PMID: 20082134 Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the...
令人惊讶的发现,CRM197包含典型的肝素结合位点XBBXBX(SEQIDNO6)的基于序列的基序,其中B是赖氨酸或精氨酸和X是亲水残基(CardinAD,WeintraubHJ.,1989:Molecularmodelingofprotein-glycosaminoglycaninteractions.Arteriosclerosis9:21–32)。该基序位于CRM197受体-结合结构域中并包含以下氨基酸:GRKIRMRCR(SEQIDNO7),其中G(...