Top Life Sciences Startups to Watch in 2023 2022 Endpoints Women in R&D Latest News October 22, 2024|Press release Epicrispr Biotechnologies Presents Data on Powerful Gene Reactivation with GEMS Epigenetic Editors at ESGCT More epicrispr news...
WORKING AT EPICRISPR Epicrispr Biotechnologies is a place where people can advance their careers, do groundbreaking work, and make a real impact on the world. Careers at Epicrispr Awards 2023 Fierce Biotech’s Fierce 15 2023 Endpoints 20 Under 40 2023 Labiotech Six Biotech spinouts yo...
Moreover, CRISPRepi supports the investigation of editing potentials for newly designed sgRNA sequences in a cell/tissue-specific context. By providing a user-friendly interface for searching and selecting optimal editing designs across multiple organisms, CRISPRepi serves as an integra...
CRISPRepi收集整合了6个物种的多种组学数据,包括人类、小鼠、拟南芥、黑腹果蝇、褐家鼠和大肠杆菌,共计671个精心整理的RNA-seq、ChIP-seq、Bisulfite-seq、CUT&Tag和ATAC-seq数据集,涉及87种细胞类型、283个靶基因、74种表观基因组编辑系统、5种Cas蛋白和35种效应蛋白以及5962条sgRNA。CRISPRepi整合了用于分析编辑结果...
Scientific Advisory Board Claire M. Fraser, Ph.D. Institute for Genome Sciences, University of Maryland School of Medicine David Schaffer, Ph.D. University of California, Berkeley Yang Shi, Ph.D. Ludwig Institute for Cancer Research, University of Oxford...
2024年11月12日,北医三院基础医学研究中心毛凤彪研究员、生殖医学中心赵晓璐副研究员团队与北京大学基础医学院李开龙研究员联合在Nucleic Acids Research(《核酸研究》IF:16.6)杂志上在线发表题为《CRISPRepi: CRISPR表观基因组编辑的多组学图谱》(CRISPRepi: a multi-omic atlas for CRISPR-based epigenome editing)的研...
OBJECTIVE. We investigated allele-specific CRISPR epigenetic editing (Epi-Allele) to selectively suppress mutant Myh6 allele expression without affecting total expression, as a novel HCM therapy in a mouse model. RESULTS. We first generated C57R403Q/DBA mice to simulate heterozygous HCM patients. ...
本发明公开了一种基于epiCRISPR技术的lncRNANRON同心肌分化相关性检测方法,所述的检测方法采用hESCs体外诱导分化形成的心肌细胞作为体外分化模型,利用epiCRISPR技术构建hESCs细胞lncRNANRON敲除株及空载对照细胞株,对内部引物及外部引物的PCR产物凝胶电泳挑选纯合敲除细胞株和杂合敲除细胞株,将构建好的两组细胞株进行体外诱导...
82: A Custom Epidrug Crispr Knockout Screen Identifies Rgfp966 (Hdac3 Inhibitor) As A Radiosensitizer of Small Cell Lung Cancerdoi:10.1016/S0167-8140(20)30974-9Mary ShiMansi AparnathiSafa MajeedLifang SongBenjamin LokRadiotherapy and Oncology...