9 月 3 日，由 18 位来自多国科研机构的成员组成的“人类生殖系基因组编辑临床应用国际委员会” （International Commission on the Clinical Use of Human Germline）发布报告，称基因编辑技术 CRISPR 不能满足有效和可靠地对人类胚胎完成精确基因编辑的条件，也无法完全避免不可预计的编辑失误；在未能达到这一标准...
The recent discovery and use of CRISPR/Cas9 gene editing technology has provided new opportunities for scientific research in many fields of study includin... RM Giersch,GC Finnigan - 《Yale Journal of Biology & Medicine》 被引量: 1发表: 2017年 Mastering targeted genome engineering of GC-rich ...
The ease of use and robustness of this technology have revolutionized genome editing for research ranging from fundamental science to translational medicine. Initial successes have inspired efforts to discover new systems for targeting and manipulating nucleic acids, including those from Cas9, Cas12, ...
The use of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) in cancer therapy has the potential to revolutionize the way for treating different diseases [1]. CRISPR technology allows for precise and efficient manipulation of the genome, and its application in cancer research has the ...
Precision medicine is now possible thanks to cancer genome sequencing. Having advantages over limited sample requirements and the recent development of biomarkers have made the use of NGS a major leap in personalized medicine. Tumor and cell-free DNA profiling using NGS, proteome and RNA analyses, ...
have potential for therapeutic genome editing.In cardiovascular medicine, the focus of therapeutic genome editing is on the liver to reduce blood LDL-cholesterol levels.The high efficiency and specificity of new CRISPR tools could enable therapeutic genome editing of inherited cardiac and vascular disease...
Two other NASEM reports wrestling with emerging genetic technologies--gene drives and mito- chondrial transfer--echo these recommendations, and the gene drive report is explicit in the use of AG as a governance strategy (National Academies of Science, Engineering, and Medicine 2016a, 2016b). As...
For Dr. Amato, figuring out how to edit disease out of an embryo safely and effectively should be an imperative, an extension of medicine as we know it. 60 Minutes' Nichole Marks produced Whitaker's piece on CRISPR this week on the broadcast. In the video above, she says the debate ove...
Section “Challenges of genome editing in the era CRISPR-Cas9” traces the challenges of genome editing in the era of CRISPR-Cas9, including the factors that differentiate CRISPR-Cas from other gene editing techniques, the research scandal from China in Fall of 2018 involving the use of this ...
6.2. Use of CRISPR/Cas System to Target Viruses in Animals Inhibition of viral infection with CRISPR-Cas systems has also been explored in animal and human medicine. Numerous studies have already demonstrated the downregulation of viral infection in animal cell cultures. These studies have employed ...