What is CRISPR technology? The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) system is a simple, rapid, and efficient means to make changes to genetic sequences directly in cells. Derived from com...
4.Holtzman L, Gersbach CA. Editing the Epigenome: Reshaping the Genomic Landscape. Annu Rev Genomics Hum Genet. 2018 Aug 31;19:43-71. doi: 10.1146/annurev-genom-083117-021632. Epub 2018 May 31. PMID: 29852072. 5.University of California - San Francisco. "New CRISPR technology offers unr...
参考资料: [1] Yang and Doudna, (2023). CRISPR technology: A decade of genome editing is only the beginning. Science, https://doi.org/10.1126/science.add8643 ▎药明康德内容团队编辑 本文来自药明康德内容团队,欢迎转发,谢绝转载到其他平台。 ,或者点赞、评论、分享给其他读者吧!
[2] Almeida RS, et al. CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer. Genes (Basel). 2022 Nov 4;13(11):2029. [3] Mills C, et al. A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs. CRISPR J. ...
June撰写的题为Emerging Use of CRISPR Technology — Chasing the Elusive HIV Cure的评论。评论认为“该工作的安全状况似乎是可以接受的,尽管相关数据仅限于该病例研究。值得注意的是,为了确保方法的安全性,需要更长时间对病人进行随访。一个令人瞩目的方面是,本研究报告将基础研究快速转化成为了临床1期试验。而在...
CRISPR是一种可编程的基因组工程技术,它已彻底改变了生物医学和生物工程研究。而不论是CRISPR的发现,还是基于CRISPR、有望解决众多难题的技术开发,都离不开计算工具。 因开发了CRISPR基因组编辑技术,Jennifer A. Doudna和Emmanuelle Charpentier共同获得了2020年诺贝尔化学奖。CRISPR是规律间隔成簇短回文重复序列(clustered ...
这一获批的技术平台不仅能够实现碱基编辑，还能够通过使用其他的相关技术，扩大碱基编辑的作用范围，为基因编辑治疗创造更广泛的人类遗传条件。“碱基编辑是一个强大的技术，可以处理其他基因编辑技术难以处理的大量遗传病”，哈佛大学技术发展办公室（Office Of Technology Development）商业发展主任 Vivian Berlin 说。图丨...
This Review intends to provide an informative summary of the latest developments and breakthroughs of CRISPR technology, with a focus on achievements and potential utility in plant biology. Ultimately, CRISPR will not only facilitate basic research, but also accelerate plant breeding and germplasm ...
Efficient sequence-specific isolation of DNA fragments and chromatin by in vitro enChIP technology using recombinant CRISPR ribonucleoproteins. Genes Cells 21, 370–377 (2016). Article CAS PubMed Google Scholar Liu, X. et al. In situ capture of chromatin interactions by biotinylated dCas9. Cell ...
根据 FDA 的一份新闻稿，这些基因编辑的猪肉产品对 alpha-gal 糖过敏的人是安全的。尽管我们很难预测 CRISPR 编辑的动物，到底将以多快的速度通过美国的审批程序，但他们已经在路上了。支持：Ren 原文：https://www.technologyreview.com/2023/01/20/1067125/crispr-farmed-animals-bigger-stronger-healthier/ ...