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Nature Reviews Clinical Oncology volume 16, pages 281–295 (2019)Cite this article 13k Accesses 137 Citations 162 Altmetric Metrics details Abstract In the past decade, the development of a genome-editing technology mediated by CRISPR has made genetic engineering easier than ever, both in vitro ...
Currently, various applications of CRISPR/Cas9 are used in cancer biology and oncology to perform robust site-specific gene editing, thereby becoming more useful for biological and clinical applications. Many variants and applications of CRISPR/Cas9 are being rapidly developed. Experimental approaches ...
Oncology Quantro Therapeutics and the future of drug discovery: Insig... Sales & Marketing Sponsored Health Trends 2025: Reimagining What's Possible Join the conversation, on Tuesday 28th January @ 10 am ET - 3 pm GMT - 4 pm CET, in our webinar sponsored by Syneos Health, entitled ...
近期,上海交通大学蔡宇伽/王大威团队在Journal of Hematology & Oncology(IF=28.5)在线发表题为“Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening”的研究论文。该研究利用CRISPR全基因组...
Precision oncology is a branch of oncology that focuses on gene-directed, histology-agnostic treatments that are tailored to each patient based on biomarker analyses. Tumor and cell-free DNA profiling using NGS, as well as proteome and RNA analyses and a better understanding of immunological systems...
此外，拜耳也宣布了全球范围内的裁员计划，以推出新的运营模式。其他公司如赛默飞、Dewpoint Therapeutics、Ikena Oncology和Hookipa Pharma等也纷纷宣布了裁员计划。进入2024年3月，裁员风波并未平息。Xilio Therapeutics宣布将裁员15人，约占其现有员工总数的21%。拜耳则在其位于新泽西州的美国总部裁员90人。此外，BMS在...
神经元去靶向重组溶瘤HSV-1的构建及其限制性因子PARP1的鉴定(图源自Journal of Hematology & Oncology) 综上所述,该工作系统性地发现并克服了溶瘤疗法的多种影响疗效的限制性因素,提出了一种基于溶瘤病毒的协同治疗策略,为诸如胶质母细胞瘤、三阴性乳腺癌和黑色素瘤等恶性肿瘤的临床治疗提供了参考。
1 Piel, F. B. The present and future global burden of the inherited disorders of hemoglobin. Hematology/Oncology Clinics 30, 327-341 (2016).2 Yin, X. L. et al. Treatment and complications of thalassemia major in Guangxi, Southern China. Pediatric blood & cancer 57, 1174-1178 (2011).3...
M. L. Roodhart (Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands) for providing the patient-derived colon cancer organoid. The Gladstone Flow Cytometry Core is supported by the James B. Pendleton Charitable Trust. The schematic in Fig....