《CRISPR人物:编辑人类的科学与伦理》 (CRISPR People: The Science and Ethics of Editing Humans) 作者:Henry T. Greely 出版社:MIT Press (2021)《破译者:Jennifer Doudna、基因编辑与人类的未来》 (The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race) ...
Here we explore the diversity of the Cas12b family and identify a promising candidate for human gene editing from Bacillus hisashii, BhCas12b. However, at 37 °C, wild-type BhCas12b preferentially nicks the non-target DNA strand instead of forming a double strand break, leading to lower ...
正如Nature杂志在题为“‘ChatGPT for CRISPR’ creates new gene-editing tools”的报道中所写:随着生成式AI的进步,现在科学家们可能只需要按一下按钮,就能设计出新的CRISPR编辑系统。 值得一提的是,除了Profluent,今年2月,来自斯坦福大学及Arc Institute的科学家团队也通过预印本平台公布了一种基于微生物基因组训...
Gene Editing through CRISPR Considered in Human ModelsRandi Hernandez
This raises a number of ethical questions that we have to carefully consider, and this is why I and my colleagues have called for a global pause in any clinical application of the CRISPR technology in human embryos, to give us time to really consider all of the various implications of doing...
the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene. Human gene ...
Watch this narration by Yasmin Dickinson, University of Oxford, to learn more about the history of CRISPR and gene editing. A Brief History of CRISPR - Part Two Watch this narration by Yasmin Dickinson, University of Oxford, to learn more about the hist...
org/news/2020/09/heritable-genome-editing-not-yet-ready-to-be-tried-safely-and-effectively-in-humans-initial-clinical-uses-if-permitted-should-be-limited-to-serious-single-gene-diseases https://www.sciencemag.org/news/2020/09/commission-charts-narrow-path-editing-human-embryos ...
6. Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., et al. (2015). CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.Protein Cell6, 3...
4. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.Protein Cell.2015;6(5):363-372. doi:10.1007/s13238-015-0153-5 5. Large deletions induced by Cas9 cleavage.Nature.2018;560(7717):E8-E9. doi:10.1038/s41586-018-0380-z ...