2024, Gastroenterology Citation Excerpt : At E16.5 when the gut has been fully colonized, virtually all cells of the ENS of Phox2bFLP;R26FLTG embryos, encompassing both SOX10+ and SOX10− cells, were consistently TOM+ (100%, n = 4238 cells from 5 embryos; Figure 7F–J). These findin...
Supplementary Fig.4. Together, our results revealed that the enhanced RNA splicing accompanied by reduced energy metabolism are associated with a severe form of HSCR. Identification ofHDAC1as a key regulator across the HSCR severity axis We next aimed to determine the pathway(s) that are ...