Definition CREB is an activator that recognizes the consensus CRE site. It is also found at additional DNA sequences (AP1 and GRE sites) in a complex containing other activators. The transcriptional activity of CREB is dynamically regulated by phosphorylation. The most well studied phosphorylation si...
CREB stands for cyclic‐AMP response element (CRE) binding protein and is a transcription factor. When phosphorylated by cyclic AMP- and cyclic GMP-dependent Protein Kinases or other protein kinases it binds to gene promoters that contain a specific binding site. After binding, the respective ...
Cyclic AMP response element binding protein (CREB) is a 43 kD basic leucine zipper transcription factor that binds theCRE(cyclic AMP response element) consensus motif TGACGTCA. CREB was originally isolated as the protein that bound CRE in the somatostatin gene. CREB was first shown to be activa...
A CRE (cyclic AMP-response element) binding protein that requires phosphorylation at a serine residue at position 119 or 133 for transcriptional activity. Transactivation of CREB by PK-A requires the glutamine-rich constitutive activator domain (Q2) and the kinase inducible domain (KID, 58 amino a...
About this entry Cite this entry (2008). CREB/cAMP Signaling. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_1371 Download citation .RIS .ENW .BIB DOI Publisher NameSpringer, Berlin, Heidelberg ...
Definition Cyclic AMP response element binding protein (CREB) is a 43 kD basic leucine zipper transcription factor that binds the CRE (cyclic AMP response element) consensus motif TGACGTCA. CREB was originally isolated as the protein that bound the CRE in the somatostatin gene. CREB was first ...
© 2013 Springer-Verlag Berlin Heidelberg About this entry Cite this entry (2013). CREB. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_100496 ...
By selectively activating and inactivating a potent transcription factor in a rat's Nucleus Accumbens (NAc), a main pleasure center in the brain, scientists at the McLean Hospital in Belmont, Mass., might have found a link between cAMP response element-bin...
Cyclic AMP-responsive element binding protein (CREB) is a transcription factor that was originally discovered and characterized from studies of hormone-induced cAMP-dependent regulation of cellular functions. In particular, CREB was found to be critical for stimulus-induced somatostatin upregulation downstr...
(2012). CREB (Cyclic AMP-Responsive Element-Binding Protein). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_100301 Download citation .RIS .ENW .BIB DOIhttps://doi.org/10.1007/978-1-4419-0461-4_100301 Publis...