CREB/CRTC2蛋白-蛋白相互作用抑制剂可调控下游糖异生相关基因的表达，通过抑制糖异生降低空腹血糖。2022年1月11日，中国科学院上海药物研究所柳红研究员与复旦大学刘浥教授、南京中医药大学胡立宏教授合作在Nature Communications上发表题为A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by...
正常状态下,crtc2处于磷酸化状态并通过结合14-3-3蛋白定位与细胞质。当细胞内钙离子和camp信号升高时,crtc2被钙调磷酸酶去磷酸化,进入细胞核,作为转录调控因子与creb结合从而参与糖异生和内质网应激相关的基因的转录,糖异生的增加是ii型糖尿病等高血糖表型疾病的典型表现。另外,crtc2/creb转录活性的升高也是脂代谢...
CREB调控转录辅激活因子2(CRTC2)重组蛋白 Recombinant CREB Regulated Transcription Coactivator 2 (CRTC2)TORC2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2物种Homo sapiens (Human,人) 相同的名称,不同的物种。
CRTC2抗原;CREB调控转录辅激活因子2(CRTC2)重组蛋白多种属 该基因编码受调节的cAMP反应元件结合蛋白活性家族转录辅激活子转导子的成员。这些蛋白质促进cAMP反应元件结合蛋白靶向基因的转录,因此在许多细胞过程中起着重要作用。在基础条件下,编码的蛋白质被AMP激活的蛋白激酶或盐诱导激酶磷酸化,并被隔离在细胞质中。 详...
Crtc2/Creb复合物阻断多肽及其衍生药物多肽和应用 (57)摘要 本发明涉及Crtc2/Creb复合物阻断多肽 及其衍生药物多肽和应用,其氨基酸序列如SEQ IDNO:1所示,可以用于制备治疗肥胖、脂肪 肝、高脂血症和2型糖尿病药物。所述的药物多 肽包括靶向抑制Crtc2/Creb复合物形成的阻断功 能结构域和穿膜功能结构域,所述靶向...
2009. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis . Nature 460 :534–537Wang Y., Vera L., Fischer W. H., Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature . 2009; 460 (7254):534–537. doi: 10.1038/...
(CREB-regulated transcription coactivator2,CRTC2)又名TORC2,是调节糖异生相关基因转录的关键因子.InsR/IRS/AKT是传统的胰岛素信号传递通路.结合本课题组前期工作... 张志红 - 《重庆医科大学》 被引量: 1发表: 2012年 2015年中国动物遗传学研究领域若干重要进展 证明在果蝇基因组中存在腺嘌呤的N6-甲基化;揭示...
Crtc2 À / À Th17 cells also had lower mRNA amounts for NR4A2, a well-established CREB/ CRTC2 target that has been shown to regulate Th17 differentia- tion and autoimmune disease (Fig. 1d)18,21. Despite these effects, mRNA amounts for other Th17 genes, including the retinoic acid ...
CRTC2 has been found to promote glucagon-regulated gene expression after its association with CREB (18, 33). Thus, we evaluated the role of CRTC2 in mediating the effects of glucagon on hepatic Bmal1 during fasting. Overexpression of CRTC2 dramatically elevated Bmal1-Luc activity, the mRNA ...
Here, we examined CREB Regulated Transcriptional Co-activator 2 (CRTC2), a known converging point between β-adrenergic receptor and calcium in glucose metabolism. Little is known about the function of CRTC2 in cardiomyocytes. Upon comparison of survival and cardiac function of wildtype and ...