Cell culture studies identified a CBP-binding small molecule called ischemin that could help prevent ischemia and reperfusion injury. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business eXchangedoi:10.1038/scibx.2011.572None...
CREB binding protein (CREBBP; CBP); p53 Cell culture studies identified a CBP-binding small molecule called ischemin that could help prevent ischemia and reperfusion injury. Further details on the research, next steps and licensing status are discussed in the article. None - SciBX: Science-Busine...
Trichostatin A (TSA), a specific inhibitor of histone deacetylases (HDACs), induces acetylation of various non-histone proteins such as p53 and α-tubulin. We purified several acetylated proteins by the affinity to an anti-acetylated lysine (AcLys) antibody from cells treated with TSA and ...
interacts with several transcriptional regulators such as TATA-binding protein (TBP) (Schaffar et al., 2004), CREB-binding protein (CBP) (Steffan et al., 2000), Sp-1 (Li et al., 2002), TBP-associated factor II 130 (TAFII130) (Dunah et al., 2002), and p53 (Steffan et al., ...
其次,为了阐明CREB对氧化应激诱导的细胞凋亡的调控机制,进行了蛋白印迹分析,发现CREB显著上调了促凋亡因子Bak和Bax的表达及其上游调控因子P53的乙酰化.为了探讨CREB调节P53乙酰化的分子机制,对P300,CBP,PCAF,GCN5四种常见的乙酰化酶进行了蛋白水平上的表达分析和检测,研究结果表明CREB能上调这四种乙酰化酶的表达.并...
卵巢癌组织中CREB结合蛋白和P53蛋白的表达及其临床意义 目的检测CREB结合蛋白(CBP)和P53蛋白在卵巢癌中的表达,明确CBP突变的位置在氨基端还是羧基端,并分析CBP和P53蛋白的表达与临床病理特征之间的关系以及他们之间的相关程... 余志华,马静方,杨春雨,... - 《重庆医学》 被引量: 10发表: 2013年 内毒素血症巨...
本文关注与突触可塑性密切相关的环腺苷酸反应元件结合蛋白( cAMP responsive element-binding protein,CREB) ,总结 CREB 的结构,激活途径,下游基因及对记忆的调控作用,关注 CREB 与 AD 的联系,为基于神经可塑性的 AD 的研究提供参考. 【 关键词】 CREB;突触可塑性;长期记忆;阿尔茨海默病 【 中图分类号...
cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. Oncogene 2007; 26: 5070–5077. 43 Hlobilkova A, Ehrmann J, Knizetova P, Krejci V, Kalita O, Kolar Z. Analysis of VEGF, Flt-1, Flk-1, nestin ...
p53, a non-histone substrate of CBP/p300, is one candidate that is considered to play a key role in mediating the cell death effect regulated by the aPKC-CBP/p300 pathway. CBP/p300-mediated p53 acetylation has been shown to increase p53 protein stability and enhance the binding of p53 to...
protein CREB结合蛋白 CBP CREB-binding AML acute myeloid leukemia 急性髓细胞白血病 ALL acute lymphocytic leukemia 急性淋巴细胞白血病 domain 激酶诱导区域 KID kinase-inducible syndromes 骨髓增生异常综合征 MDS myelodysplastic anemia 难治性贫血 RA refractory RAS Refractory anemia with ring sideroblasts 难治性...