Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a Gαi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system including microglia, as well as intestinal and kidney macrophages. Cx3cr1CreERT2 mic...
此外,现有的转基因品系如Sall1-GFP、Sall1-CreERT2、Cx3cr1-GFP、Cx3cr1-Cre或Cx3cr1-CreERT2通常是替代性敲入策略产生的,即表达外源性敲入的序列,内源性基因不表达,但是该类策略有可能会影响小胶质细胞的表型,因此,迫切需要新的基因工具来对小胶质细胞进行研究。 为此,南模生物自主研发,构建了一种新的小...
Here, we address this issue by using the inducible Cre/loxP system to trace β-cells. We generated Ins2-CreERT2/R26R-YFP double knock-in mice, in which pancreatic β-cells can be labeled specifically and permanently upon injection... K Nakamura,K Minami,K Tamura,... - 《Biomed Res》 ...
Using a stomach-specific CreERT2 system, we created mice that develop tumors with morphologic similarities to subtypes of human gastric cancer. These tumors have different patterns of local growth, metastasis, and response to therapeutic agents. They can be used to study different subtypes of human...
Furthermore, Cre activity could be selectively induced in extra-embryonic and embryonic endoderm lineages, the primitive gut tube, and in endothelial cells of the vascular system as well as in the hemogenic endothelium of the dorsal aorta. The Sox17CreERT2 mouse line therefore represents a new...
Molecular architecture of the mouse nervous system Cell, 174 (2018), pp. 999-1014.e1022 View in ScopusGoogle Scholar Cited by (1) Do catecholaminergic TrkC DRG neurons represent a class of cardiovascular enteroceptor? 2022, Cell Reports Show abstract ...
Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a Gαi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system including microglia, as well as intestina
In the parenchyma of the central nervous system, NG2-expressing (NG2+) cells have been identified as a novel type of glia with a strong potential to generate oligodendrocytes (OLs) in the developing white matter. However, the differentiation potential of NG2 glia remained controversial, largely...
【关键词】造血系统;造血干祖细胞;c.ki t+细胞;ERn.cre;Rosa26R—YFP报告基因系统文献标识码:A中图分类号:Q 813;Q 78文章编号:1673-4181(2014)05—0266—05Condi ti ons andeffi ci encyof Rosa26R- YFPreporter gene systeml abel ed m ouse hem atopoi eti c stem andprogeni tor cel l s i ...
These data suggest that the expression of Mds1-Evi1 in the fetal hematopoietic system is remarkably transient, in contrast to the expression of Mds1-Evi1 in adult LT- and ST-HSCs (Zhang et al., 2011). Generation of a mouse model of TAM-inducible Cre recombinase knocked into the Mds1 ...