CRD3874-SI demonstrated high levels of systemic safety in cynomolgus monkeys, thought to be related to its ability to inhibit STING proton channel activity.Methods:This is a single institution, phase 1a/b study of CRD3874-SI in patients with advanced sarcoma and Merkel cell carcinoma who have ...
Methods Anti-cancer activity of CRD3874-SI by the IV route was evaluated in human STING KI C57/BL6 mice (Genoway) in various murine tumor models. PBMCs were used to measure cytokine levels and THP1 cells were used for the measurement of autophagy and inflammasome markers. Results Intravenous...