Patients were treated with a CPT-11 starting dose of 100 mg/m2 body surface given as a 90-minute intravenous (IV) infusion every week with subsequent doses based on toxicity. Fifteen patients were assessable for toxicity, response, and survival. Results: Seven patients (47%; 95% confidence...
in several phase II trials as active agents for relapsed SCLC, we conducted a phase II study to evaluate the efficacy and toxicity of CPT-11 combined with weekly CDDP and VP-16 (PE) in patients (pts) with SCLC who had relapsed at least 8 weeks after completion of first-line therapy. ...