For example, SD-101 was effective in 78% of patients with unresectable melanoma in combination with PD-1 inhibitors [36]. However, naked CpG ODN are clinically limited due to their rapid degradation and low efficiency of delivery to immune cells. To overcome these limitations, various non-...
Study Design: To test the hypothesis that ibrutinib will enhance the efficacy of in situ vaccination via its effects on T-cells, we initiated a phase I/II clinical trial combining oral ibrutinib (560mg), intratumoral CpG (SD-101, 3mg) and local low-dose radiation in patients with recurrent...
结果表明,SD‑101可缩小局部肿瘤的体积,但不能对远处的肿瘤产生抑瘤作用。相比之下,MBS513‑1能够缩小局部和远处肿瘤的肿瘤体积。 [0130]总之,从该审查员处获得的结果表明:与单体对应物相比,呈二聚体形式的CpG寡核苷酸显示出更好的抗肿瘤效果。更令人惊讶的是,局部注射二聚体CpG寡核苷酸诱导了全身性抗肿瘤...
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XC7A50T-2CPG236I是赛灵思Xilinx公司的一款FPGA芯片,具有以下性能和应用: 性能: - 50,000个逻辑单元(Look-Up Tables) - 1,800个数字信号处理单元(DSP) - 900个存储块(Block RAM) - 最大时钟频率为400MHz - 支持多种通信协议,如PCI Express、Gigabit Ethernet、USB等 应用: - 通信系统:可用于...
(ODN) containing unmethylated CpG motifs have been identified as TLR-9 agonists, which could trigger innate and adaptive immunity. Until now, various CpG ODN has been studied in different stage clinical trials for cancer combinatorial immunotherapy [33,34,35]. For example, SD-101 was effective ...
Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L et al (2005). DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development 132: 3345. Feng J, Chang H, Li E, Fan G (2005). Dynamic expression of de novo DNA methyltransferases...
SD-101 in combination with pembrolizumab in advanced melanoma: Results of a phase Ib, multicenter study. -(′,′-dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP): Prolonged liposome retention mediates stronger Th1 responses.(1), 153–161...
LTC3633AEUFD-1、TISP4250J3BJR-S、MIC5332-NNYMT-TR、WJLXT6155LE、RL875S-392K-RC、SCD1004T-270M-N、NRS4018T330MDGJ、Hi3516CRBCV100、AR8032-BL1A、XC95108-20PC84C、S-8241ADMMC-GDMT2G、TPS40100RGETG4、WP144GDT、SDWL2012CR12JSTF、HLMP-EL32-PS000、CY2318ANZPVC-11T、HY57V561620BLTC-10...
responseofCT26toanti–PD-1corre-latedwithincreasedT-andB-cellinfiltrationandIFNexpression.WeshowthatintratumoralinjectionofahighlyinterferogenicTLR9agonist,SD-101,inanti–PD-1nonrespondersledtoacom-plete,durablerejectionofessentiallyallinjectedtumorsandama-jorityofuninjected,distant-sitetumors.Therapeuticefficacyof...