分别注射SD-101或非活性非CPG寡核苷酸(CTRL-ODN),同时继续抗PD -1治疗(图A、B);同理使用PD-L1抗体也有相同的效果(图C、D);CT26双侧成瘤鼠,治疗侧给药,未治疗侧肿瘤也缩小了,并诱导长期生存效应--13/19 (68%)(图E);这一效应需要CD8+而不需要CD4+ T细胞,因为只有CD8+T细胞缺失的小鼠才会...
结果表明,SD‑101可缩小局部肿瘤的体积,但不能对远处的肿瘤产生抑瘤作用。相比之下,MBS513‑1能够缩小局部和远处肿瘤的肿瘤体积。 [0130]总之,从该审查员处获得的结果表明:与单体对应物相比,呈二聚体形式的CpG寡核苷酸显示出更好的抗肿瘤效果。更令人惊讶的是,局部注射二聚体CpG寡核苷酸诱导了全身性抗肿瘤...
结果表明,SD‑101可缩小局部肿瘤的体积,但不能对远处的肿 瘤产生抑瘤作用。相比之下,MBS513‑1能够缩小局部和远处肿瘤的肿瘤体积。 [0130] 总之,从该审查员处获得的结果表明:与单体对应物相比,呈二聚体形式的CpG寡 核苷酸显示出更好的抗肿瘤效果。更令人惊讶的是,局部注射二聚体CpG寡核苷酸诱导了全 身性...
For example, SD-101 was effective in 78% of patients with unresectable melanoma in combination with PD-1 inhibitors [36]. However, naked CpG ODN are clinically limited due to their rapid degradation and low efficiency of delivery to immune cells. To overcome these limitations, various non-...
Nilsson CL, Dillon R, Devakumar A, Shi SD, Greig M, Rogers JC, Krastins B, Rosenblatt M, Kilmer G, Major M: Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells. J Proteome Res. 9: 430-443. Abassi YA...
(see text).dIGV plots for the top 3 EMT genes from panelc.esiRNA loss-of-function assays for the top three genes followed by expression measurement of established mesenchymal markers.n = 3 biologically independent experiments. Data are presented as mean ± SD.p-values were determined by ...
The Z-score of each HCC-detecting marker was defined as the number of SDs above the mean, where the SD and the mean were calculated according to the plasma samples from normal individuals. All MCTA-Seq and RRBS data have been deposited to the NCBI under accession number GSE63775. ...
Sassetti C, Tangemann K, Singer MS, Kershaw DS, Rosen SD: Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. J Exptl Med. 1998, 187: 1965-1975. 10.1084/jem.187.12.1965. Article CAS Google Scholar Sassetti C, Van Zante A...
CPG晟邦电机24V送电刹车电机CH-1-100-30SD CH-2-200-40SD C... 晟邦单相220V立式电机城邦电机CPG电机CV-200-30ACV-400-2CV-2 晟邦邦电机,城邦电机,CPG , CV-400S CV-750S CV-1500S。 城晟邦精密机电(上海)有限公司 第1年 上海市松江区 主营产品: 减速电机 刹车电机 减速机 控制器 变频电机...
Data are mean ± SD of determinations from three independent experiments. ap < 0.001 and bp < 0.01, vs Un-transfected; cp < 0.001 and dp < 0.01, vs Scrambled-siRNA. Granulocyte-colony stimulating factor, G-CSF; Interleukin, IL; Keratinocyte-...