Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China Wenqiang Liu & Shaorong Gao ...
MATERNAL IMMUNE ACTIVATIONFETAL-BRAIN DEVELOPMENTSYSTEMIC INFLAMMATIONDNA METHYLATIONCHILDREN BORN28TH WEEKCOGNITIVE IMPAIRMENTPRETERM NEWBORNSAGEPROTEINSBackground:Infants born extremely premature are at increased risk for health complications later in life for which neonatal inflammation may be a contributing ...
Exclusion cri- teria were congenital malformations, maternal autoimmune disease, maternal intake of immunomodulatory drugs (except for prenatally administered betamethasone for induction of fetal lung maturation), chorioamnionitis, signs of maternal clinical infection, or elevated infection markers (C-reactive...
10. The method of claim 1 further comprising the step of: testing one or more members of the library of sequences which are enriched for sequences derived from methylated CpG islands to identify sequences which are differentially methylated between maternal and paternal chromosomes. 11. The method...
6. Li YF, Langholz B, Salam MT, Gilliland FD: Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005, 127:1232–1241. 7. Miller RL, Ho SM: Environmental epigenetics and asthma: current concepts and call for studies. Am J Respir Crit Care Med ...
6. Li YF, Langholz B, Salam MT, Gilliland FD: Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005, 127:1232–1241. 7. Miller RL, Ho SM: Environmental epigenetics and asthma: current concepts and call for studies. Am J Res...
In utero smoke exposure from maternal smoking has been associated with changes in both global DNA methylation and methylation of specific genes[11, 12, 14, 15]. Moreover, various components of AAP that are shared with SHS (for example, PAH) have been found to impact DNA methylation[3, 11...
The MBD method can be used as an effective tool in the detection of methylated fetal specific markers with a high CpG density in maternal plasma.Ji HyaeLimDa EunLeeKyeong SunKimHyun JinBom YiSo YeonParkClinical chemistry and laboratory medicine...
MBD2−/− mice appear normal but do exhibit a defect in maternal nursing behavior, whose exact cause is still unclear 64. On the other hand, the MBD3−/− mutation is embryonic lethal, consistent with the possibility that MBD3 is a necessary component for NuRD complex and involved in...
Maternal use of e-cigarette (e-cig) aerosols poses significant risks to fetal brain development, potentially increasing susceptibility to neurodevelopmental disorders in later life. However, the underlying mechanisms remain incompletely understood. This study aimed to understand the effects of fetal e-cig...