CpG island methylatorphenotype-low(CIMP-Low)colorectal cancer shows notonly few methylated CIMP-high-specific CpG islands,butalso low-level methylation at individual loci. TAKAKO KAWASAKI,MUTSUKO OHNISHI,KAT-SUHIKO NOSHO,et al. ModernPathology . 2008...
cpg island methylator phenotype 读音:美英 cpg island methylator phenotype基本解释 CpG岛甲基化表型;岛甲基子表型;CpG岛甲基化现象 分词解释 cpg合格程序生成器(CertifiedProgramGenerator) island岛,岛屿vt. 使孤立 methylator甲醇化物vt.混入甲基 phenotype显型...
CpG island methylator phenotype CpG islands are genomic regions containing a large number of cytosine and guanine nucleotides, located in 5’ regulatory regions (promoter regions) [44–49]. The CpG island methylator phenotype (CIMP) is the most recently identified mechanism of colon cancer carcinogene...
肾上腺皮质癌(Adrenocortical carcinoma,ACC)是一种罕见的侵袭性肾上腺内分泌癌。在肾上腺皮质癌中,最近研究表明以CpG岛甲基化表型(CpG island methylator phenotype,CIMP)为特征的亚型与特别差的预后相关。然而CIMP的驱动因素仍然未知。此外,CIMP与肾上腺皮质癌患者临床预后不良之间的功能关系尚不明确。 2023年8月2日,法国...
Wisplinghoff, Köln, Deutschland Synonym(e) CIMP Englischer Begriff CpG island methylator phenotype (CIMP) Definition Der Begriff CpG-Island-Methylator Phenotype (CIMP) wird in Verbindung mit einer Untergruppe von Tumoren benutzt, bei denen eine tumorspezifische Methylie- rung von Promotorbereichen ...
CpG island methylator phenotype (CIMP) In some cancers, a large number of CpG islands are simultaneously methylated, and such a phenotype is designated as the CpG island methylator phenotype. CIMP can be associated with specific cancer pathophysiology, such as patient prognosis and drug sensitivity....
Hill VK, Shinawi T, Ricketts CJ, Krex D, Schackert G, Bauer J, Wei W, Cruickshank G, Maher ER, Latif F (2014) Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas. BMC Cancer 14:506 Central...
CpG岛甲基化现象(CpG Island Methylator Phenotype,CIMP)是指启动子区CpG岛异常甲基化现象,抑癌基因的启动子区异常甲基化,导致抑癌基因转录沉默,与多种肿瘤形成密切相关[2,3]。CIMP阳性分型被确定为一个独特的表观遗传学现象,在结直肠癌、神经胶质瘤、胃癌、乳腺癌、肝细胞癌、肾透明细胞癌等多种肿瘤中存在 [3...
Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn 2007;9:305–314. 17 Frigola J, Song J, Stirzaker C, et al. Epigenetic remodeling in colorectal cancer results in coordinate 409 Modern Pathology (2011) 24, ...
在正常组织里，70%～90%散在的CpG是被甲基修饰的，而CpG岛则是非甲基化的。正常情况下，人类基因组“垃圾”序列的CpG二核苷酸相对稀少。并且总是处于甲基化状态，与之相反，人类基因组中大小为100-1000bp左右，富含CpG二核苷酸的CpG岛则总是处于未甲基化状态。当CpG岛出现甲基化表型，涉及到多个基因...