CpG 1018, a 22-mer CpG ODN containing sequence with a modified phosphorothioate backbone14, is the adjuvant used in the licensed hepatitis B vaccine HEPLISAV-B, and is the only TLR9 agonist used in an approved vaccine. In this study, we present data from preclinical studies aimed at ...
2.权利要求1所述的方法,其中所述的CpG佐剂是CpG 1018、CpG 2216、CpG 2336、CpG VIP免费下载 下载文档 收藏 分享赏 0 下载提示 1、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。 2、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问加QQ:3005833200。
CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to be safe and well tolerated in humans when administrated via the pulmonary route. In contrast, ISS inhalation has unexplained toxicity in ...
The first element was generated by random shuffling of the DNA sequence while retaining the CpG-sites (roughly 20% of total sequence) at their original position without changing the overall nucleotide composition (CscrCpG). The second element was designed by randomly shuffling the complete DNA ...
Toll-like receptors (TLRs) are part of the innate immune system, and they belong to the pattern recognition receptors (PRR) family. The PRR family is designed to recognize and bind conserved pathogen-associated molecular patterns, which are not generated by the host and are restricted and essent...
Figure 4. DNA Sequence and Methylation Are Critical Factors in DNA Fragment Immune Complex Activation of AM14 B Cells Proliferation of AM14 B cells in response to ICs formed between Hy1.2 and varying concentrations of either TNP-conjugated CG50 DNA (TNP2-CG50-TNP), a TNP-conjugated DNA frag...
ODN 1018 TLR9 agonist - CpG ODN, Class B (Human/mouse) ODN 1668 TLR9 Agonist - CpG ODN, Class B (Mouse) ODN 1826 TLR9 Agonist - CpG ODN, Class B (Mouse) ODN 2006 TLR9 Agonist - CpG ODN, Class B (Human) ODN 2007 TLR9 Agonist - CpG ODN, Class B (Bovine/porcine/...
The Class B CpG 1826 ODN is a mouse TLR9 agonist. InvivoGen CpG ODNs are functionally tested and guaranteed endotoxin-free to avoid non-specific immune stimulation. The sequence of CpG-B (type K) ODN 1826 is tccatgacgttcctgacgtt.
Genebank中选择 Genome选项,搜索并下载百日咳杆菌(Bordetella pertussis)基因组全序列,将全序列文件导入Vector NTI Advancell软件;查阅文献,获取三条具有抗变应性哮喘活性的 CpG-ODNs (0DN-1018、0DN-1026、0DN-3234);应用 vector NTI Advance 软件比对(Blast) 已知效应序列0DN-1018、0DN-1026、0DN-3234与百日咳...
CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans. J Clin Invest. 2009; 119 :2564–2576.Campbell, J. D.; Cho, Y.; Foster, M. L.; Kanzler, H.; Kachura, M. A.; Lum, J. A.; Ratcliffe, M. J.; Sathe, A.; Leishman,...