MECP2pedia: A Comprehensive Transcriptome Portal for MECP2 Disease Researchdoi:10.1101/2021.11.27.470197Ying-Wooi WanAlexander Jonathan TrostleLucian LiSeon-Youn KimJiasheng WanRami Al-OuranHari Krishna YalamanchiliZhandong LiuCold Spring Harbor Laboratory...
7 RNA-seq Median Gene TPMs by Tissue (www.gtexportal.org), RettBASE MECP2 Variant List (mecp2.chw.edu.au/mecp2/mecp2_home.php), and UniProt Cluster ID: UniRef50_Q9Z2D6 (www.uniprot.org/uniref/UniRef50_Q9Z2D6). Source data are provided with this paper. Code availability Custom...
Monica Justice and colleagues performed a genetic suppressor screen in Mecp2-null mice, which recapitulate symptoms of Rett syndrome, a neurological disease with autistic features. They identify a nonsense suppressor mutation in Sqle, which encodes a rat
Since gene expression patterns are regulated by promoters, it is very important to identify the cis-acting elements in promoters [9]. The promoter is a DNA sequence upstream of the 5′-flanking region of the structural gene and is capable of specifically recognizing and binding RNA polymerase, ...
利用CRISPR基因编辑技术,在Mecp2基因exon 2-3两侧分别插入loxP位点。该flox大鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Mecp2基因的大鼠模型。 应用领域:Rett综合征,自闭症 *使用本品系发表的文献需注明: Mecp2-Flox(SD) rats (Cat. NO. NR-CKO-200001) were purchased from Shanghai...
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CARGO: a web portal to integrate customized biological information There is a huge quantity of information generated in Life Sciences, and it is dispersed in many databases and repositories. Despite the broad availability ... C Ildefonso,DG Pisano,A Eduardo,... - 《Nucleic Acids Research》 被引...
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RNAseq data of the gene expression are available for download at TCGA (https://www.cancer.gov/), GTeX (https://gtexportal.org/), TARGET (https://software.broadinstitute.org/cancer/cga/target), and treehouse (https://treehousegenomics.soe.ucsc.edu/public-data/). The full names of all ...
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