Since then, a second isoform of COX, named COX-2, has been discovered and highly selective inhibitors of this isoform have been marketed. Most recently, a splice variant of COX-1 mRNA, retaining intron 1, and given the names COX-3, COX-1b or COX-1v, has been described. Non-...
Therefore, two Cox-2 inhibitor scelecoxib and indomethacin were chosen to test this possibility. Although both inhibitors could reverse PA-reduced Akt phosphorylation in a dose dependent manner, it is evident that celecoxib had much higher potency than indomethacin (Fig. 5D,E). Both inhibitors ...
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