We focused on immune responses, vaccine effectiveness, and safety of the COVID-19 vaccine. Vaccination could elicit antibody titers and cellular T cells responses in frail elderly adults. SARS-CoV-2 infection, hospital admission, and mortality in residents and staff ...
“The rush to create a COVID-19 vaccine may do more harm than good” (Torreele2020). The article lamented the fact that a vaccine may only provide short term protection or may offer only low vaccine effectiveness (less than 50%). The article quotes Phil Krause, then deputy...
The vaccination procedure included two jabs, and five quantities of the vaccine were evaluated in the tests: 5 micrograms, 10 micrograms, 15 micrograms, 20 micrograms and 25 micrograms. The study highlighted that 15 microgram doses induced the highest titers of neutralising antibodies, roughly double...
Immunogenicity of CoVac-1 was determined in terms of CD4+and CD8+T cell responses to the six SARS-CoV-2 HLA-DR vaccine T cell epitopes as well as to embedded HLA class I-binding peptides (Supplementary Table1) using IFNγ enzyme-linked immunospot (ELISPOT) assays. T cell responses were ...
New data from Novavax's ongoing research on its updated XBB.1.5 COVID-19 vaccine in participants who previously received an mRNA vaccine showed robust neutralizing antibody titers for the XBB.1.5 subvariant as well as for the currently circulating JN.1 subvariant. Data also showed that the vac...
it is also the first COVID-19 vaccine announced internationally that has high titers of neutralizing antibodies against Omicron. Animal experiments conducted with sequential vaccination of different types of COVID-19 vaccines showed that two doses of mRNA/inactivated...
“Fortunately, neutralization titers induced by vaccination are high, and even with a 6-fold decrease, serum can still effectively neutralize the virus,” Fauci and 2 NIAID colleagues wrote in aJAMAeditorialposted February 11. And, they noted, lower vaccine efficacy in the South African clinic...
Although the COVID-19 vaccine candidates promise to overcome the pandemic, a more significant and clear understanding is needed. In this review, we brief about the clinical trial of some leading candidates, their effectiveness, and their neutralizing effect on SARS-CoV-2 variants. Further, we ...
showed that the titers of IgG anti-SARS-CoV-2 in HWs were more reduced in those receiving influenza + COVID-19 vaccines than in those receiving only COVID-19 vaccine32. Differences in methods, cohorts and antigens could explain the conflicting results. In our cohort, HWs reported a ...
The world's first aerosolized inhaled adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV), jointed developed by CanSino Biologics (CanSinoBIO) and researchers from the Institute of Military Medicine under the Academy of Military Sciences led by Chen Wei, was proven safe in Phase-I ...