病毒的中合抗体(Virus NAb,neutralizing antibody)激活了抗体的Fc受体,使得巨噬细胞响应发生偏移和创伤愈合反应丧失,并产生单核细胞趋化蛋白(MCP-1,Monocyte chemoattractant protein-1, )和白细胞介素8 (IL-8)。而且中和抗体激活补体系统(complement system)和抗体依赖细胞介导的细胞毒性作用(ADCC,antibody dependent c...
SARS-CoV-2 RNAs are present in diverse epithelial and immune cells Megakaryocytes and monocyte subsets may contribute to cytokine storms Summary Dysfunctional immune response in the COVID-19 patients is a recurrent theme impacting symptoms and mortality, yet the detailed understanding of pertinent immun...
如下图展示了CD14 monocyte中IFITM3基因的表达情况,每个点代表一个样本的pseudo-bulk数据。 2. 不同条件下的差异基因列表。如 mild/moderate vs healthy, severe vs healthy, severe vs mild/moderate,progressionstage vs remission stage 3. 细胞组成与发病时间、分型、性别及年龄的关系。下图展示了CD14 monocyte中...
which was strikingly upregulated in monocyte after vaccination, together with CD14, FPR1, C5AR1, NAMPT, NLRP3, CDKN1A, and IFNGR2. Whereas, MVS-negative set correlated well with “Cytotoxicity signature”, represented by...
so we did not examine these cell types further. These analyses revealed the conspicuous presence of four cell populations that were uniquely present in the COVID-19 patients (albeit to different extents in the severe vs. remission disease stages), including a monocyte subpopulation (cluster 9), ...
髓系:CD14 monocyte, CD16 monocyte, Neutrophils, SC&Eosinophil, DC, pDC 淋系: CD4n T, CD4m T, IFN-stim CD4 T, CD8m T, gdT NK B, IgG PB, IgM PB, IgA PB proliferating lymphocytes 红细胞和血小板:RBC, Platlet 新细胞群:Developing neutrophil ...
很多分子参与了单核细胞穿越血管壁的迁移(monocyte trafficking)。评估不同COVID-19严重程度下溢出级联反应(extravasation cascade)的marker表达,结果显示这些基因在nrMa中出现了显著的增强。ITGAL (编码CD11a), ITGAM (编码CD11b), ITGAX (编码CD11c), ITGB1 (编码CD29)和ITGB1 (编码CD18) 以及LFA-1, Mac-1和...
Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patients. Preprint at medRxiv https://doi.org/10.1101/2020.03.03.20030437 (2020). Zheng, M. et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell. Mol. Immunol. https://...
[74], possibly due to impaired protein synthesis eliciting ER stress-induced apoptosis via unfolded protein response (UPR) [75]. Since beta-coronavirus-induced UPR has been shown to modulate innate immunity [76], targeting aberrant monocyte/macrophage activation may be another possible intervention ...
Thus, the virus reproduces and is released by monocyte-macrophages along with a large amount of IL-6, TNF-α, and other cytokines, culminating in a cytokine storm and T cells downregulation. This condition is related to the severity of COVID-19 and negatively correlated with pro-inflammatory...