vaccineimmune responseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2; 尾CoV), the causative agent of coronavirus disease 2019 (COVID-19), causes severe lower respiratory tract infections and acute respiratory failure syndrome (ARDS). Deaths due to the ongoing COVID-19 pandemic for ...
COVID-19 mRNA and inactivated vaccines are currently the most widely used vaccine types in the world during the COVID-19 pandemic. Studies have shown that mRNA vaccination of recovered patients strongly enhances the breadth and potency of the humoral immune response against SARS-CoV-224,25. Howev...
UK, and AstraZeneca in Cambridge, UK, get another vaccine for their second dose. Researchers hope that such mix-and-match COVID-19 vaccinationregimenswill trigger stronger, more robust immune responses
A phase 2 trial of an Ad5 vectoredCOVID-19 vaccine candidate, conducted in China, has found that the vaccine is safe and induces an immune response, according to new research published inThe Lancet. The randomized trial sought to evaluate the safety and immunogenicity of the vaccine cand...
Acandidate vaccine for Covid-19 developed by the drug maker Moderna appears to generate an immune response similar to the response seen in people who have been infected by the virus and recovered, the company said Monday. In a Phase 1 trial, eight patients who received two doses of the va...
Scientists are using powerful genomics technologies to explore this and other major questions around the host immune response. Their discoveries will help inform the selection of therapies for clinical trials, vaccine development, and defining high-risk groups. ...
为了最大限度地发挥疫苗接种的效益,Emerging Microbes & Infections发表的最新研究Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates(异源初免-加强免疫: 打破COVID-19候选疫苗的保护性免疫反应瓶颈) 探索了采用异源的主要增强策略的效用,在小鼠模型中对中国...
These data suggest that protection may require low levels of NAbs and might involve other immune effector mechanisms including non-NAbs, T cells and innate immune mechanisms. Identifying the mechanisms of protection as well as correlates of protection is crucially important to inform further vaccine ...
As explained in thisBBC article, the lining of the womb (the endometrium) contains immune cells. Because the COVID vaccine affects the immune system, it's possible that the vaccine could affect the way the lining of the womb is building up and breaking down; this could explain why your pe...
However, given that these patients were not included in the pivotal clinical trials, considerable uncertainty remains regarding vaccine efficacy, and the extent of humoral and cellular immune responses in these patients, as well as the risks of vaccine-related adverse events. In this Review, we ...