At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset ...
Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention JAMA, 323 (13) (2020), pp. 1239-1242, 10.1001/jama.2020.2648 View in ScopusGoogle Scholar Wu...
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. Transl. Res. https://doi.org/10.1016/j.trsl.2020.04.007 (2020). Article PubMed PubMed Central Google Scholar Leatherdale, A. et al. Persistently elevated ...
Additionally, the extract was found to downregulate the expression of inflammatory markers such as Ikβα, TNF-α, and IL-6 in SARS-CoV-2 infected Huh7 cells, suggesting that it might alleviate the cytokine storm induced by SARS-CoV-2 infection [63]. Similarly, TCMs such as Lianhuaqingwen...
The model assumes a linear relationship between the independent and dependent variables, which may not be accurate for all cases. Additionally, the model does not consider the impact of external factors, such as political and cultural factors, which can significantly affect e-government service ...
On March 10, 2023, the Johns Hopkins Coronavirus Resource Center ceased its collecting and reporting of global COVID-19 data. For updated cases, deaths, and vaccine data please visit the following sources: Global:World Health Organization (WHO) ...
IL-6 and JAK/STAT signaling JAK/STAT signaling plays a pivotal role in regulating cell growth, survival, differentiation, motility, and immune responses. This pathway mediates the effects of a large number of cytokines and growth factors. Aberrant hyperactivation of the JAK/STAT pathway may result...
大多数国家认为IL-6升高是一个严重和关键的临床预警指标。根据COVID-19患者的临床资料,促炎细胞因子和趋化因子可以避免细胞因子风暴的风险,实现自愈的可能性,这也是大多数轻、中度患者可以治愈的原因[95]。然而,一些轻症患者也因免疫疾病而经历了细胞因子风暴。这...
We searched for IL-18 inhibition as a possible treatment option for severe COVID-19 using the keywords “COVID-19” and “IL-18” in clinicaltrials.gov and found no registered clinical trials. Accordingly, we think that IL-18 inhibition can provide a therapeutic option in patients with ...
This API provides updated real-time data on coronavirus cases from the worldometers page, provided by the most reputable organizations and statistical offices in the world. - ChrisMichaelPerezSantiago/covid19