Of 120 papers, we found only one randomized clinical trial. Of the 67 original studies, 22 were cohort, and 28 were cross-sectional studies. Of the total 120 publications, 49.1% focused on signs and symptoms, 23.3% on management, and 10.8% on pathophysiology. Ten publications focused on ima...
Focosi D, Franchini M, Pirofski L-a, et al COVID-19 convalescent plasma and randomized clinical trials: rebuilding confidence by explaining failures and finding signals of efficacy. medRxiv. 2021:2021.2009.2007.21263194. doi:10.1101/2021.09.07.21263194Google Scholar 35. US Food...
Clinical characteristics of COVID-19 in New York City. N Engl J Med. 2020;382(24):2372-2374. doi:10.1056/NEJMc2010419 PubMedGoogle ScholarCrossref 40. Tocilizumab in the treatment of coronavirus induced disease (COVID-19) (CORON-ACT). ClinicalTrials.gov identifier: NCT04335071. ...
While many unanswered questions remain, the etiology of Covid-19-associated coagulopathy appears to follow Virchow’s Triad (Fig.5). The inclusion of thrombosis substudies in ongoing clinical trials of anti-viral, anti-inflammatory and immune-modulating therapies is strongly encouraged as are dedicate...
We note that during this period, the RECOVERY Collaborative Group reported results of randomised clinical trials demonstrating the lack of efficacy of hydroxychloroquine21 and the efficacy of dexamethasone22 in COVID-19 patients on June 5th 2020 and June 16th, respectively—which significantly impacted ...
You can register any type of research athttp://www.researchregistry.comto obtain your UIN if you have not already registered. This is mandatory for human studies only. Trials and certain observational research can also be registered elsewhere such as:ClinicalTrials.govor ISRCTN or numerous other...
monitoring board for trials sponsored by AstraZeneca. C.J.S. is an academic lead on KCL Zoe Global Ltd. COVID symptoms study. The remaining authors declare no competing interests. Peer review Peer review information Nature Communicationsthanks the anonymous reviewer(s) for their contribution to ...
However, some clinical trials and research studies could not demonstrate therapeutic and preventive potential of the drug toward COVID-19 (Ayerdi et al., 2020; Del Amo et al., 2020). Protease inhibitors such as lopinavir-ritonavir and darunavir are tested for anti-SARS-CoV-2 activity. It ...
No data is obtained regarding prophylactic treatment for COVID-19, although many clinical trials are underway. Conclusion The most effective weapon is prevention and precaution to avoid the spread of the pandemic. In this current review, we outline pathogenesis, diagnosis, treatment, ongoing clinical...
(detached form) may restrict SARS-CoV-2 entry into pulmonary endothelial cells by attaching itself to the virus. Treatment of COVID-19 patients with a human recombinant soluble ACE2 (hrsACE2) is already under clinical trials (Zhang et al.2020a,b,c,d,e). Furthermore, ADAM-17 contributes...