Though various strategies such as sequential passaging of the virus in murine lung and intestinal tissue [166] and adaptation of SARS-CoV-2 by reverse genetics aimed to modify the receptor-binding domain of SARS-CoV-2 are proposed to enhance infectivity in mice [167], few rare viruses in th...
starting from breathing difficulties, chest problems, but also include other common problems such as fatigue, fever, pain, neurological deficits including difficulty focusing, headaches, problems sleeping, tingling & numbness, dizziness, delirium, systemic symptoms such as ear, nose, and throat problems,...
This may be because the SARS-CoV-2 replicates in the gastrointestinal tract and then infects and destroys absorbent intestinal cells. Or the gastrointestinal system is directly damaged by the COVID-19 induced inflammation [138]. Meanwhile, we observed that the prevalence of diarrhea decreased with...
E.g. depression, anxiety, asthma, joint problems, cancer, diabetes, intestinal problem, cardiac illness.), questions to assess moderate to vigorousphysical activitylevels (MVPA) using the Exercise Vital Sign (EVS) questionnaire (Coleman et al., 2012), questions surrounding sedentarybehaviour(Armstrong...
Visible physiological abnormalities like aggressive systemic inflammation, dysregulated immune system responses leading to hepatic cirrhosis, and intestinal dysbiosis seems to be possible pathogenesis of liver ailments with the progression of COVID-19 [4]. Meanwhile, the possibility of overexpression of ...
The present clinical methods for COVID-19 treatment mainly include antiviral and antibacterial drugs, anti-inflammatory drugs, anti-SARS-CoV-2 antibody, oxygen therapy, and intestinal microecological agents and plasma from patients in rehabilitation [92, 93]. It is widely understood that patients in...
The need to address the foundations of public health and healthcare in India around the problems of market failure and low state capacity has never been greater. Irfan Khawaja,Policy of Truth Alienation and double-thinkChris Dillow,Stumbling & Mumbling ...
In December 2019, a new coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and associated disease, coronavirus disease 2019 (COVID-19), was identified in China. This virus spread quickly and in March, 2020, it was declared a pandem
route for entry of SARS-CoV-2 into the human host, the digestive tract is also one of the probable sources of the infection as the COVID-19 symptoms are allied with the alveolar epithelial cells of the lungs and enterocytes or intestinal absorptive cells of the human small intestine [31]....
In both cases, the S protein of SARS-CoV binds to the human zinc peptidase ACE2, which is expressed in a range of tissues such as the lung, heart, kidney, and intestinal cells. Both the N- and C-terminal S1 subunits contain the receptor-binding domain (RBD), while the C-terminal ...