Here, we use whole genome sequencing in 7,491 critically-ill cases compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical Covid-19. We identify 16 new independent associations, including variants within genes involved in interferon ...
王立铭《病毒科学 9 讲》 Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility.
WHO’s Science in 5 on COVID-19: Genome Sequencing Vismita Gupta-Smith: We are talking about genome sequencing today. How does it help us track diseases? And in this phase of the pandemic, what is the trend we are...
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. ---/ END /--- 点击加入基因俱乐部 成就行业精英 目前已有500+行业精英加入基因俱乐部
参考资料 王立铭《病毒科学 9 讲》 Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. ---/ END /---
Reinfection cases were confirmed by whole-genome sequencing. From 19 March 2020 to 31 March 2021, 1644 (mean age, 38.4 years and 57% male) participants were enrolled; where 1080 (65.7%) were tested negative and added to the negative cohort. The positive cohort included 750 positive patients ...
Meanwhile, the whole genome sequencing analysis of 16 cases announced earlier confirmed that they all carried the Omicron variant of COVID-19, bringing the total number of Omicron infections to 533 in Hong Kong.■ A resident registers personal information in Kwai Chung of Hong Kong, south China...
nursing home outbreakcovid-19 epidemiologyphylogenetic treewhole genome sequencinghousehold transmissionBackgroun:d Residents in nursing homes are at risk of high morbidity and mortality due to coronavirus disease 2019 (COVID-19). We report the first nursing home...
The Omicron subvariant BA.2.75 has been detected in New Zealand for the first time. Analysis of whole genome sequencing has confirmed two cases in New Zealand with BA.2.75. Before testing positive for COVID-19, both cases had recently traveled to India, where this subvariant has been detecte...
The flow diagram of rare variants analysis. A total of 32,232,865 variants were identified from the 451 Covid-19 patients with whole genome sequencing. After filtering by VQSR and MAF, 13,934,341 rare variants were annotated by VEP, and 42,730 candidate variants were included. ...