最近仍在进行的一项II期研究(NCT04374461)旨在评估NAC(iv;6克/天)给药对COVID-19严重症状患者的影响;其结果将有助于阐明该药物对COVID-19患者的潜在治疗特性[63]。 此外,一项病例报告研究表明,口服和静脉注射2000mgGSH,均可有效缓解COVID-19的严重呼吸...
[27]LUR J, ZHAOX, LIJ, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding[J]. Lancet, 2020, 395(10224): 565-574. [28]WRAPPD, WANGN S, CORBETTK ...
There have been reports of COVID-19 infection in animals and this gives credence to the zoonotic potentials of this deadly virus. In this mini-review, we evaluate the zoonotic potentials of COVID-19, the viral structure and?mechanism that will likely favor COVID-19 inter-hosts transmission,?
在COVID-19患者中观察到的心脏损伤是直接由SARS-CoV-2感染引起还是间接由COVID-19的并发症所引起目前尚不清楚,而且由于心内膜活检受采样误差的限制,再加之通常只有部分患者接受该检查,因此,目前关于SARS-CoV-2对心肌的直接损害证据相对有限,未来期望出现更大规模心内膜活检及尸检的相关心脏病理学证据,进而明确SARS-C...
[27] LUR J, ZHAOX, LIJ, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding[J]. Lancet, 2020, 395(10224): 565-574. [28] WRAPPD, WANGN S, CORBETTK S, et al. Cryo-EM structure of the 2019-nCoV spike in the...
Fig. 1. Coronavirus structure. Coronaviruses are enveloped, non-segmented virus with a positive‐sense single‐stranded RNA and phosphorylated nucleocapsid (N) protein. Presently, whole genome sequence of nCoV-2019 is available in GenBank (accession number MN908947) (Phan, 2020). Pair-wise sequenc...
［7］ 重症新型冠状病毒感染肺炎诊疗与管理共识（武汉同济医院新型冠状病毒肺炎救治协作组）［J］. 内科急危重症杂志，2020，26（1）：1-5. Diagnosis，treatment and management consensus of severe corona virus disease 2019（COVID-19 treat ment cooperation group of Wuhan Tongji hospital ） ［J］. J ...
最近的研究表明,严重COVID-19可发展为急性呼吸窘迫综合征(ARDS),这是肺纤维化的主要诱发因素,不可逆转地损害呼吸功能。COVID-19最严重的后遗症主要表现在气道,应该首选将药物直接吸入肺部,因为可以降低使用剂量和全身副作用。尽管需要进一步研究来优化这些技术,最近的研究还显示了体外模型对于重建SARS-CoV-2感染和...
Anti-COVID-19 Compound Library Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease structure (PDB ID: 6LU7). In combination with the reported results of 3CL protease (Mpro)-based virtual sc...
5 Walls, A.C., et al. (2020) Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell 181, 281-292.e286 6 Kuhn, J.H., et al. (2004) Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus. ...