Crystal structure of COVID-19 Mproin complex with N3 inhibitor;aone protomer of the dimeric Mpro–inhibitor complex, where green sticks represent N3 inhibitor;bdepicts surface of the dimeric Mpro–inhibitor complex, where blue-coloured part represents protomer A, salmon-coloured part represents Pr...
最近仍在进行的一项II期研究(NCT04374461)旨在评估NAC(iv;6克/天)给药对COVID-19严重症状患者的影响;其结果将有助于阐明该药物对COVID-19患者的潜在治疗特性[63]。 此外,一项病例报告研究表明,口服和静脉注射2000mgGSH,均可有效缓解COVID-19的严重呼吸...
Based on this, several bioinformatic analyses were performed to understand the involvement of these genes in the biological processes of the organism. In addition, we attempted to elucidate the pathogenic molecular mechanisms of these genes in COVID-19 and predict potential therapeutic agents. These ...
Genetic factors contributing to COVID-19 susceptibility and severity may provide new biological insights into disease pathogenesis and identify mechanistic targets for therapeutic development or drug repurposing, as treating the disease remains a highly important goal despite the recent development of vaccines...
alterations in the microbiome after SARS-CoV-2 infection might contribute to acute and long COVID symptoms. In this article, the author reviews the detrimental effects of COVID-19 on the brain, and the biological mechanisms (e.g., EBV reactivation, and changes in the gut, nasal, oral, or...
斯坦福大学的一项新研究表明,与COVID-19有关的压力因素从物理上改变了青少年的大脑,使他们的大脑结构看起来比COVID-19流行前可比的同龄人的大脑老几岁。该研究于2022年12月1日发表在《生物精神病学:全球开放科学》上。 仅在2020年,成年人的焦虑和抑郁症报告就比往年增加了25%以上。新的发现表明,COVID-19对青少...
19 are still very limited. Resveratrol is a non-flavonoid polyphenol compound with natural activity,which has antioxidation, antiviral, anti-inflammatory, anti-tumor and other biological pharmacological activities. This paper di...
2. Global statistical data and current scenario of COVID-19 pandemic 3. Structural and biological configuration of SARS-CoV-2 4. Similarity of SARS-CoV-2 with SARS-CoV and MERS-CoV 5. Mode of transmission, symptoms, and entry mechanism of SARS-CoV-2 6. Immune response against SARS-CoV-...
Many variants of SARS-CoV-2 have appeared. These mutations usually do not have a decisive effect on the biological behavior of the virus and do not make a significant change in its structure and composition [54]. Variant B.1.1.7 of SARS-CoV-2 appeared in the United Kingdom in September...
structure of virus transmission, but this study also lacks the corresponding attitude data of individuals. Finally, the contact network only can capture part of the dynamic transmission process of COVID-19. Merging more data with the network data, such as virus biological data, community ...