Since the onset of the pandemic, SARS-CoV-2 has evolved substantially in the spike protein1, which harbours all epitope sites for neutralizing antibodies elicited by vaccines or infection2. For example, the Omicron lineages BA.1 and BA.2 contained multiple alterations in spike epitopes, allowing...
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We also included, as measures of spatiotemporal differences, the calendar week of enrollment and geographic region of receipt of care defined by Veterans Integrated Services Networks (VISN). In consideration of the dynamicity of the pandemic, for analyses that compared BTI, SARS-CoV-2 infection ...
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of influenza and SARS-CoV-2 in community-tested patients in France during the 2023-2024 season and to assess VE against a positive test for influenza (VEf) and SARS-CoV-2 (VECov) according to time since vaccination, calendar week, viral types or clades, and the association with viral ...
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Among males aged 16 to 24 years, adjustment for calendar period (model 3) yielded unstable point estimates with wide CIs for the second dose of mRNA-1273. Heterogeneity of the analyses across countries was not statistically significant (eFigure 2 in the Supplement); thus, we present the ...
There are several strengths of this study that make it well-suited for evaluating vaccine protection against any SARS-CoV-2 infection. Due to mandated weekly surveillance testing for the majority of the 2021 calendar year in conjunction with the temporal dynamics in SARS-CoV-2 viral shedding45,...
Well, according to the calendar, I am now in day 67 of my self-imposed isolation in my apartment, working from home for my employer, the University of Manitoba Libraries. I have not set foot in a supermarket since March 16th, and I have not set foot in a pharmacy since January 30th,...
This ongoing, open-label, phase 2/3 trial compared the safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent mRNA-1273.222 vaccine with the ancestral Wuhan-Hu-1 mRNA-1273 as booster doses. Two groups of adults who previously received mRNA-1273 as primary vaccination series an...