TMZ methylates guanines in DNA at the O6 position, leading to base-pair mismatch. The known O6– methylguanine (O6–MeG) lesion causes DNA double-strand breaks and subsequent cell death through autophagy, apoptosis, or both [87]. MGMT is the DNA repair enzyme that repairs the O6-MeG lesion...
Ethylenediaminetetraacetic acid; IDH1: Isocitrate dehydrogenase-1; GFAP: Glial fibrillary acidic protein; EMA: Epithelial membrane antigen; MS-PCR: Methylation-specific polymerase chain reaction; PCR-SSCP: PCR single-strand conformation polymorphism; FISH: Fluorescent in situ hybridization; NCCN: National ...