This is the first randomized trial to demonstrate both OS and rPFS benefits in chemo-naive mCRPC and that inhibition of persistent extragonadal androgen synthesis significantly delays initiation of cytotoxic chemo. While median OS (AA arm) has not been reached, median PL arm OS (27.2 mos) is ...
Prostate Cancer Journal Club - Radiographic Progression-free Survival as a Response Biomarker in Metastatic Castration-resistant Prostate Cancer: COU-AA-302 Result Charles Ryan, MD discusses the results of a randomized trial of mCRPC patients which showed that radiographic PFS was high...