METHODS. We integrated decision tree and Markov model to calculate incremental costs per quality adjusted life-year saved for universal genetic testing for Lynch syndrome relative to using preliminary tumor tests (immunohistochemistry or microsatellite instability) followed by DNA sequencing test for ...
Use of gene tests to detect hereditary predisposition to cancer: what do we know about cost effectiveness? Mutations in 4 genes associated with DNA repair have been shown to be associated with hereditary non-polyposis colon cancer (HNPCC) in families which displ... ML Brown,LG Kessler - 《Int...
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Without genetic tests of parentage, descriptions of mating systems must be considered hypothetical. Here we confirm the existence of cooperative polyandry ... J Faaborg,PG Parker,L Delay,... - 《Behavioral Ecology & Sociobiology》 被引量: 469发表: 1995年 Confirmation of cooperative polyandry in ...
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The discovery of BRCA1 and BRCA2 genes has led to the introduction of increasingly sophisticated genetic tests to measure the risk of hereditary breast cancer, among other things. The aim of this study was to determine the prevalence of the mutation in 24 women from Córdoba with breast / ova...
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Costs for each proce- dure, utilizing reimbursement data for insurer 2 in Table 1, were multiplied by the number of tests done based on a prob- ability that the test would be needed (Table 2). The totals for each procedure were summed to provide total cost estimates for each model. We...
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Our field survey showed that sex ratios were significantly biased toward females in many populations of the sexual strain (17 of the 32 populations,p < 0.05 based on binomial tests after Bonferroni corrections). Here, the sexual:asexual ratios were negatively correlated with the sex ratios (...