Richard MortimerAlan WhiteChristian Frois
For complex biologic products, such as insulin, it is impossible to make the identical product15. The term “biosimilars” is used (instead of “generics”) for products that are almost identical in composition, pharmacologic properties, and clinical effects. Biosimilar approval process is more cumb...
Adults and children 12 years of age and older with moderate to severe eczema (atopic dermatitis [AD]) that did not respond to previous treatment and their eczema is not well controlled with other pills or injections, including biologic medicines, or the use of other pills or injections is not...
Facile genetic transfection of target cell populations is an indispensable aspect of modern molecular biology, involving the introduction of DNA/RNA substituents or other cell impermeable reagents (biologic drugs, peptides, etc.) to alter signaling responses of target cells1,2. Often, this results in...
Biosimilars to originator bevacizumab (Avastin), such as bevacizumab-bvzr (Zirabev), can deliver substantial savings and/or expanded access to biologic therapy for patients with metastatic colorectal (mCRC) and non-squamous non-small cell lung cancer (mNSCLC). The objective of this study is to ex...
The majority of APIs on the market (roughly 70 percent)4 are small molecules chemically synthesized from crude oil and natural gas, and thus contribute a much higher share of carbon emissions relative to biologic APIs grown from cell cultures or small organisms.5...
but were na茂ve to tumor necrosis factor antagonists (i.e., biologic drugs).Cost-effectiveness analysis using a hybrid model structure (decision tree and Markov model) MEASUREMENTS AND MAIN RESULTS: A decision tree simulated biologic induction, and a Markov model simulated biologic and conventional...
Biologic drugs have been used in English rheumatology for 25 years and have transformed patients' lives and the specialty itself. All rheumatology departments are bound by guidance from the National Institute for Health and Care Excellence and the British Society for Rheumatology; often also by local...
Efficacy, Tolerability and Cost Effectiveness of Disease-Modifying Antirheumatic Drugs and Biologic Agents in Rheumatoid Arthritis Over the last decade, several new drugs have become available for the treatment of patients with rheumatoid arthritis. These agents include the new disease... DMT Nurmohamed...
This analysis assessed the cost per responder (CPR) of bimekizumab, a humanised monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, compared to approved IL-17A inhibitors ixekizumab and secukinumab, in the management of plaque psoriasis (PsO), ...