and personal care products. We are a great fit for growth-mode beauty brands that need a trusted partner to reliably compound and fill. We have the equipment, people, processes, and experience to take your business to the next level. We are FDA licensed and GMP certified. Beaty brands have...
For retinol, skin uptake was over-estimated, but this very lipophilic compound has a log P that falls outside the range encompassed by data that was used to develop the Potts & Guy algorithm and is locally metabolised, underlining the importance of applying expert judgment to this approach. ...
For example, indented scars that are the result of acne can be treated with injectable dermal fillers, such as Juvéderm® or Restylane®. Both Juvéderm® and Restylane® involve injecting hyaluronic acid into the treatment areas. Hyaluronic acid is a glycosaminoglycan (a sugar-based compoun...
1,4-Dioxane is a synthetic compound mainly used as solvent in industrial based products for instance paints, waxes, polishes, inks and varnishes. It is also present in cosmetic formulations and personal care products as dispersants, lathering agents and emulsifiers1,2,3. In the meantime, the ...
Clearance was calculated by the amount of compound eliminated and the average concentration of the target compound in the plasma (CL= A/P, where A is the amount of compound eliminated from the plasma and P is the average plasma concentration). Since the AUCs (AUCall and AUCinf) of BCP ...
In the USA, the system is more simplified, with cosmetics compound products needing to be in line with the Federal Food, Drug and Cosmetic Act (FDA) and the Fair packaging and Labelling Act of the Fair Trade Commission [83]. In Japan, the cosmetics regulation is very similar to the one...
Because it is a hydrophilic compound with a big molecular weight (674.57 g/mol), it has a very low skin penetration (around 1% of the dose applied) [104]; therefore, it has a good safety profile. 10.3. Drometrizole Trisiloxane It has a 2-(2-hydroxyphenyl)-2H-benzotriazole scaffold ...
However, this result was not as effective as in the case of the other tested compound, erythrosine. The authors then tested a concomitant application of both compounds and verified a synergistic effect suggesting that Cy3glu may have an interesting role in bacterial PDT. In another study, ...
This compound has USFDA GRAS status showing low systemic toxicity and associated mortality at high concentrations in many experimental models [24]. The most common polyphenolic substances are phenolic acids, flavonoids, stilbenes or lignans. Many studies have confirmed that various polyphenolic substances...
As indicated by the SCCS guidance notes [3], due to the conservation of endocrine mechanisms across vertebrate species data provided by “some ecotox tests may be informative for the assessment of the endocrine activity of a compound in humans”. This is of great value as the additional informa...