identify better alternatives and promote drug development. While further evaluation of the effectiveness and safety of these medications is needed, they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD. 自闭症谱系障碍(ASD)是一系列以社交功能障碍和...
There are currently no effective treatments for the core symptoms of autism spectrum disorder (ASD), such as difficulties with socializing and communicating. A new study uses a computer-based protein interaction network to identify whether existing drugs could provide a new treatment approach. The res...
This complexity may explain the great difficulty in finding pharmacological therapies that can reverse or ameliorate the core symptoms of ASD efficiently and across the spectrum [7]. The current approved pharmacological treatments target the comorbid behaviors frequently observed in ASD such as anxiety, ...
[96]. however, a recent double-blind, placebo-controlled, phase 2 superiority trial in children with asd without severe intellectual disability did not show any treatment benefits on the core symptoms of asd as measured on the srs-2 [97]. it did show treatment benefits on the repetitive ...
Stereotypic and repetitive behaviors are also core symptoms of ASD. Thus, we examined whether Senp1 haploinsufficient mice have stereotypic behaviors via the restrictive and repetitive behaviors test (Figure S1G). Interestingly, Senp1 haploinsufficient mice showed more stereotypic behaviors by measuring ...
Findings regarding sex differences in autism spectrum disorder (ASD), as far as core symptoms and psychiatric comorbidities (PC) are concerned, are inconsistent, inconclusive, or conflicting among studies. The lower prevalence of ASD in females than in males and the age and intelligence quotient (...
Recent studies have suggested that long-term oxytocin administration can alleviate the symptoms of autism spectrum disorder (ASD); however, factors influencing its efficacy are still unclear. We conducted a single-center phase 2, pilot, randomized, double-blind, placebo-controlled, parallel-group, ...
using well-established paradigms with high relevance and sensitivity for the diagnostic and associated symptoms of ASD.14,15,16,17PV−/−mice not only display typical ASD-like phenotypes with relevance to all human autism core symptoms, that is, impaired social interactions, communication deficits...
Genetic mouse models represent powerful translational tools for studying the role of genetic and neurobiological factors underlying ASD. Here, we report that PV knockout mice (PV) display behavioral phenotypes with relevance to all three core symptoms present in human ASD patients: abnormal reciprocal ...
A recent study further found that mice with the ASD-linked InsG3680 mutation in SHANK3 show defective synaptic transmission in the striatum and impaired juvenile social interaction, coinciding with the early onset of ASD symptoms, while adult mice carrying the schizophrenia-linked R1117X mutation ...