Thiomolybdates, which are used in the treatment of Wilson's disease in humans and which will also block copper toxicity in sheep, appear to be useful in goats in the therapy or prevention of copper poisoning, e
Please Note: Additional (rare) overdose / toxicity symptoms are the result of a high chromium intake causing deficiencies of other elements or nutrients. These are found in their respective "Deficiency" category and include potassium, copper, vanadium, selenium, cobalt, iodine, Vitamin B12, and ...
To find new genes that might be targeted for reduction of Cu toxicity in Wilson disease we employed genome-wide shRNA screening in ATP7B-KO HepG2 cells, a bona fide WD cell model12,13. These cells do not express ATP7B (Supplementary Fig.1a, b) and consequently exhibit elevated sensitivit...
Copper toxicity symptoms include a reduced shoot vigor, a poorly developed and discolored root system and leaf-chlorosis. The toxicity can be seen at places of iron ore deposits and copper smelting. In citrus and lettuce, high copper levels induce iron chlorosis. Copper also significantly inhibits...
Copper toxicity symptoms include a reduced shoot vigor, a poorly developed and discolored root system and leaf-chlorosis. The toxicity can be seen at places of iron ore deposits and copper smelting. In citrus and lettuce, high copper levels induce iron chlorosis. Copper also significantly inhibits...
Accidental ingestion or attempted suicide are the most common causes of acute copper poisoning in humans. In contrast, chronic copper overload diseases, e.g. Wilson's disease (WD) and Indian childhood cirrhosis, may initially manifest with milder symptoms that, however, become severe and possibly...
Cultivation of crops, such as rice, in Cu-polluted lands, results in yield loss, reduced seed quality and Cu toxicity in humans. Therefore, developing rice varieties tolerant to Cu stress or understanding the overall mechanism of rice plant response to Cu toxicity is important for sustainable ...
Moreover, in humans, genetic mutations that cause Cu accumulation have been linked to severe, potentially life-threatening pathological conditions.1 Thus, understanding the process by which Cu accumulation causes cellular toxicity is an important first step toward developing new, effective therapies. Cu...
which brings blood from the small intestines that is rich in nutrients, also goes to the liver. These blood vessels divide into smaller vessels, and eventually end in capillaries, within the thousands of lobules of the liver. The lobule is the functional unit of the liver. Each lobule is ma...
Copper (Cu) is a vital mineral essential for many biological processes. The vast majority of all Cu in healthy humans is associated with enzyme prosthetic groups or bound to proteins. Cu homeostasis is tightly regulated through a complex system of Cu transporters and chaperone proteins. Excess or...