Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility of applying copper ionophores to regenerate the metal homeostasis and treat copper-related diseases. Copper ionophores alter the concentration, distribution, and reactivity of endogenous copper ions with consequent ...
Unlike copper chelators, copper ionophores like ES and DSF facilitate the transport of copper into cells to regulate intracellular copper levels. ES, a crucial component of the cuproptosis mechanism, specifically acts on mitochondrial respiration. Its therapeutic potential is due to its ability to po...
Copper ionophoresLipoylationFerredoxin 1 (FDX1)Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.#We analyzed the effect of ferroptosis inducers on copper ionophores-induced cell death through ...
Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. J Am Chem Soc. 2011;133:6235–42. Article CAS PubMed Google Scholar Hasinoff BB, Wu X, Yadav AA, Patel D, Zhang H, Wang DS, et al. Cellular mechanisms of...
In addition, there are useful tools that can bind to copper ions and help them enter cells, named copper ionophores [94]. These ionophores may increase intracellular copper toxicity. Consistent with regulation of copper transporters, Tsvetkov observed potent copper ionophore elesclomol increases coppe...
Selective targeting of cancer cells by copper ionophores: an overview Front. Mol. Biosci., 9 (2022), Article 841814 View in ScopusGoogle Scholar [147] K.C. Falls-Hubert, A.L. Butler, K. Gui, M. Anderson, M. Li, J.M. Stolwijk, S.N. Rodman, S.R. Solst, A. Tomanek-Chalkley...
The effectiveness of traditional copper ionophores and copper chelators as antitumor agents has been confirmed; however, these remedies lack selectivity [20]. Moreover, the existence of tumor heterogeneity results in different tumors having different metabolic characteristics [21]; thus, there may also...
Extracellularly, elesclomol can form a stable 1:1 complex with Cu(II) [54]. Afterward, elesclomol shuttles back and forth between the inside and outside of the cell to transport copper ions into the cell [6]. Notably, unlike other copper ionophores, such as DSF, cellular copper levels...
Copper ionophores, such as elesclomol and disulfiram, increase intracellular copper levels. This elevation triggers oxidative stress and subsequent cell death... C Springer,D Humayun,R Skouta - 《Cancers》 被引量: 0发表: 2024年 加载更多来源...
Therapeutic interventions include copper chelators (e.g., ammonium tetrathiomolybdate), and oxidative phosphorylation inhibitors like elesclomol and copper ionophores (CuII(atsm), CuII(gtsm), and disulfiram). These interventions modulate intracellular copper, elevate NO, and reduce inflammatory ...